NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：n-Butyl lactate
CAS：138-22-7

Result：


ID:	21B3047
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	-	Warning	H227: Combustible liquid	P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 4 since flash point is 71 degC (NFPA (13th, 2006)).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 382 degC (NFPA (12th, 1997)).
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance contains oxygen (but not fluorine or chlorine) in the molecule which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	A LD50 value of >2000 mg/kg for rats (PATTY (5th, 2001)) corresponds to "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification not possible due to lack of data. As relevant information, LD50 values are >5000 mg/kg for rabbits and >5000 mg/kg for rats (RTECS, 2008).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	A LC50 (4h) value of >5.14 mg/L for rats (PATTY (5th, 2001)) corresponds to "Not classified". Since the saturated vapour pressure concentration for the substance was 3.20 mg/L and the test was considered to be conducted for mists, the classification criteria for dust and mist was adopted.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Classification not possible due to lack of data. As relevant information, there is a result of "moderate irritation" after application to the skin of rabbits (RTECS (2005)).
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	There is a report that complaints of irritation of the conjunctiva were not confirmed by examination (ACGIH (7th, 2001)). Animal test data are not available. Based on these information, classification was not possible due to lack of data.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation, Narcotic effects）		Warning	H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	There is a report that prolonged exposures of humans resulted in irritation of the pharyngeal and laryngeal mucosa, with coughing, headache and sleepiness (ACGIH (7th, 2001)). A second report states: "Symptoms; irritation nose and throat, drowsiness, headache, central nervous system depression. Target Organs; respiratory system, central nervous system" (NIOSH Pocket Guide to Chemical Hazards (2005)). Based on this information, the substance was classified into Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	There is a report that occupational exposures results in irritation of the pharyngeal and laryngeal mucosa, with coughing and some workers complained of sleepiness and headache after work (ACGIH (7th, 2001)). This information indicate that the substance may possible cause damage to the respiratory system and nervous system. Classification was not possible due to lack of sufficient data.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3 from its 96h-LC50 = 75 mg/L for fish (Zebrafish) (AQUIRE, 2011).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Classified into Not classified since mean of 28d-BOD degradation rate tested by OECD TG301D (Closed Bottle Method) is 63% and the lactate is judged to be easily degradable from test results of other lactates (Bowmer et al, 1998), and low bioaccumulative potential is estimated (log Kow = 0.8 (PHYSPROP Database, 2009)).
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）