GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Synthetic vitreous fibers
CAS：
Result：
| ID: | 21B3040 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (room temperature) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (room temperature) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (room temperature) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (room temperature) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not combustible (ICSC (2000)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (room temperature) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible (ICSC (2000)) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (ICSC (2000)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Insoluble in water (HSDB (2005)) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (room temperature) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (room temperature) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Although the substance may produce itching due to mechanical effects on the skin of workers exposed during work, this is a temporary condition and can be controlled with appropriate work practices (ACGIH (2001)). Particles with a diameter of 4.5 - 5 micrometers and higher cause mechanical irritation of the skin which often disappears with continued exposure (EHC 77 (1988)). According to the Finnish Register of Occupational Diseases, for every 100,000 employed workers, only a few cases (1 to 9 cases) of irritant contact dermatitis were due to the substance, therefore the substance cannot be considered to be a common cause of occupationally induced contact dermatitis (HSDB (2005)). Based on these data, the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on a report that isolated reports of temporary irritation of the eye, especially in workers applying loose insulation, have been made but no serious or chronic problems have been associated with the substance (ACGIH (2001)), the substance was classified into Category 2B. As relevant information, there is a report that eye irritation, itching, pain, or a foreign body sensation typically develops in patients with ocular exposures (HSDB (2005)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a positive Ames test (IARC (2002)) and a positive chromosomal aberration test using human embryo lung cells (IARC (2002)). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Based on the classification of "Group 3" in IARC (IARC 81 (2002)), the substance was classified as "Not classified". As relevant information, the substance is classified into "A3" in ACGIH. No increase in lung cancer was found in rats by inhalation exposure for 12 - 24 months (ACGIH (2001), IARC 81 (2002)). In contrast, large cohort tests conducted in the United States and Europe indicate an overall elevated risk of respiratory cancer by exposure to rock wool (ACGIH (2001)). However, based on results in case?control tests with adjustment for tobacco smoking and potential occupational confounders and exposure conditions, it was reported that there is no relationship between risk of respiratory (lung) cancer and rock wool exposure (IARC 81 (2002)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
In humans, acute exposures were associated with symptoms of upper respiratory tract irritation such as nasal itching and congestion, nosebleed, sore throat, cough, and laryngeal and pharyngeal pain. These symptoms were reported to disappear shortly following cessation of exposure (ATSDR (2008)). Based on the data, the substance was classified into Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In a 24-month inhalation test in rats (ATSDR (2004)), increased pulmonary macrophages was observed at 3 months of exposure and collagen deposition at the bronchoalveolar junction was observed at 12 months of exposure at dose levels of 3.1 mg/m3/6h and higher. Following 18 - 24 months of exposure, mild fibrosis in the lung was observed at dose levels of 16.1 mg/m3/6h and higher. Since the exposure concentrations are within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system). There are numerous reports of epidemiological tests for the substance (EHC 77 (1988), HSDB (2005)). In these tests, no increased incidence of non-neoplastic lesions including pulmonary fibrosis were found due to exposure to the substance. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |