GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Ethyl 2-cyanoacrylate
CAS：7085-85-0
Result：
| ID: | 21B3036 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point 75 degC (closed-cup) (ICSC (2001)) is >60 degC and <=93 degC. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification is not possible since no data are available though there are chemical groups (unsaturated bond) associated with self-reactive properties present in the molocules. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Auto-ignition point is 485 degC (The Society of Synthetic Organic Chemistry, Japan, Dictionary of Organic Compounds, Kodansha (1985)) exceeding 70 degC. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on mortality of 1/6 at 5000 mg/kg in rats (CICAD (2001)), a LD50 value is estimated to be >5000 mg/kg. The substance was classified into "Not classified". |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on no mortality at 2000 mg/kg bw in rabbits (CICAD (2001)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, mortality was 70% in rats exposed at 21 mg/L/1h (5.25 mg/L/4h) (CICAD (2001)). |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on a report that slight erythema and slight oedema were observed, the mean score was 0.83 in a 24-hour application skin irritation test using rabbits (CICAD (2001)) and a report that human data indicate that the substance is not a skin irritant as a result of a single exposure (CICAD (2001)), the substance was classified as "Not classified". As relevant information, it has been reported from human tests that repeated exposure can result in skin irritant effects (CICAD (2001), ACGIH (2001)). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
In a rabbit eye irritation test, the irritation mean score (EU system) was 1.37 for conjunctival redness, 1.0 for corneal opacity, and 0.48 for iritis. All reactions decreased in intensity during the 72-hour observation period (CICAD (2001)). Additionally, there is a case report of an accidental exposure in which lacrimation, pain in the eye, blurred vision, and defect of the corneal epithelium occurred. 1 week later, the cornea was completely healed, and visual acuity was fully restored (CICAD (2001)). Based on the data, the substance was classified into Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Following exposure to the substance, many cases of respiratory tract symptoms such as cough, wheezing and rhinitis or asthmatic response associated with occupational exposure were reported. Additionally, significant decreases in forced expiratory volume was recorded for exposed individuals (ACGIH (2001), CICAD (2001), DFGOT (1991)). One report suggests that the use of the substance was responsible for bronchial hyperresponsiveness (CICAD (2001)). However, there is a report that the available information does not allow conclusions to be drawn regarding whether asthma was induced by an allergenic or an irritation mechanism (CICAD (2001)). Classification was not possible due to lack of a report that definitely concludes that the substance induces respiratory sensitization. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on a number of case reports (two or more cases from separate institutions) demonstrating that the substance induced skin sensitization by occupational exposure (CICAD (2001), ACGIH (2001)), the substance was classified into Category 1. As relevant information, there are many case reports that positive reaction to the substance was observed in patch tests for patients with contact dermatitis (CICAD (2001), ACGIH (2001)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on a negative result in a mouse bone marrow micronucleus test by intraperitoneal administration (in vivo somatic cell mutagenicity test) (NTP DB (1994)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames tests (DFGOT (1991), CICADs No. 36 (2001), NTP DB (1994)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
In humans, nasal irritation and subjectively recorded symptoms such as wheezing, whistling breath, and chest tightness were reported following occupational exposure (CICAD (2001)). It is reported that the substance can produce a strong local irritation as an effect on the upper respiratory tract (ACGIH (2001)). Based on the data, the substance was classified into Category 3 (respiratory tract irritation). In a rat inhalation test, severe effects such as hemorrhage in the lung were observed (CICAD (2001)), however the findings was not used as the basis of classification because of nonspecific changes in victims. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data. The questionnaire showed increases in the prevalence of some subjectively recorded symptoms relating to the respiratory tract of exposed workers, e.g., wheezing, whistling breath and chest tightness (CICAD (2001)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification was not possible due to lack of data for aspiration hazard. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |