NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：Chloromethyl methyl ether
CAS：107-30-2

Result：


ID:	21B3025
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2		Danger	H225: Highly flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 2 since flash point -17.8 degC (Merck (14th, 2006), 0 degC (HSDB (2005)), -17.8 degC (HSDB (2005)) are <23 degC and initial boiling point 59 degC (Merck (14th, 2006), Weiss (2nd, 1986)), 59.9 degC (Chapman (Ver. 13.1, 2009)) are >35 degC.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	-	-	-	-	No data available.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance contains oxygen and chlorine (but not fluorine) which are chemically bonded only to carbon.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on a LD50 value of 817 mg/kg for rats (EHC 201 (1998)), the substance was classified into Category 4. [In this test, industrial bulk which contains 1 - 8% of bis (chloromethyl) ether as impurity was used.]
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a LC50 value of 0.181 mg/L/7h (4-hour equivalence: 0.239 mg/L (72.2 ppmV)) for rats (EHC 201 (1998)), the substance was classified into Category 1. Since the test was conducted at lower than 90% of saturated vapour pressure concentration, the classification criteria for gas was adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 1		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on reports that application to the skin of animals resulted in erythema and necrosis (EHC 201 (1998)) and that contact with the substance can induce a risk of chemical injury or necrosis in humans (ACGIH (2001)), the substance was classified into Category 1.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Since there is a report that application to animal eyes resulted in corneal necrosis (EHC 201 (1998)) and the substance is classified into Category 1 for skin irritation, the substance was classified into Category 1.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since mouse micronucleus tests showed both positive and negative results, the mutagenicity is considered to be "inconclusive" (Mutat Res., 389, 3-122, 1997). In epidemiological research, the frequency of chromosomal aberrations in the peripheral lymphocytes of 77 exposed workers was approximately twice that found for 25 unexposed control workers (in vivo somatic cell mutagenicity test) (CaPSAR (1993), EHC 201 (1998)). There are reports of positive Ames and MLA tests (Mutat Res., 389, 3-122, 1997). Based on positive results from human epidemiological research, Ames test and MLA test, the substance was classified into Category 2. As relevant information, there is a report that the substance increased unscheduled DNA synthesis in a human lymphocyte unscheduled DNA synthesis test (in vitro genotoxicity test) (EHC 201 (1998)).
6	Carcinogenicity	Category 1A		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the classification of "Group 1" in IARC (IARC suppl. 7 (1987)) and "A" in EPA (IRIS (2005)), the substance was classified into Category 1A. As relevant information, the substance is classified into Category 2A (industrial) in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and "A2" in ACGIH (ACGIH-TLV (2008)). The technical grade substance is contaminated with 1 - 7% bis (chloromethyl) ether, which is a known human carcinogen, hence, the carcinogenicity of the substance is attributed to the contaminant (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (1994)).
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)		Danger	H370: Causes damage to organs (respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a report that inhalation exposure to rats produced pulmonary congestion, oedema, haemorrhage and acute necrotizing bronchitis at a LD50 of 55 ppm/7h (vapour, 4-hour equivalence: 0.239 mg/L) (EHC 201 (1998)), the substance was classified into Category 1 (respiratory system). In humans, there is information that vapour exposure to 100 ppm is dangerous to life in 4-hour, and may result in pulmonary edema or pneumonia which may cause death within a few days or a week after exposure (HSDB (2005)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In a 30-day inhalation exposure test in male rats (vapour, duration and frequency of exposure not specified), deaths occurred at 3.3 mg/L and higher concentrations and regenerative hyperplasia and squamous metaplasia in bronchial epithelium were observed (EHC 201 (1998)). However, the results were not used as the basis of classification since duration and frequency of exposure were not specified and data for unexposed controls was not presented. In humans, there is a report that the substance may produce chronic bronchitis with long-term inhalation (HSDB (2005)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）