GHS Classification Result (Revision of the past classification result)

Chemical Name:Carbon black
CAS:1333-86-4

Result:
ID: 21B3024
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification is not possible since no test data on flammability are available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is >600 degC (IUCLID (2000)) exceeding 70 degC.
11 Self-heating substances and mixtures Category 1-2 (Materials of animal or vegetable origin), Classification not possible (Materials of mineral origin) Danger H251: Self-heating; may catch fire (Materials of animal or vegetable origin) P235+P410: Keep cool. Protect from sunlight.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P407: Maintain air gap between stacks/pallets.
P413: Store bulk masses greater than ... kg/... lbs at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials.
Materials of animal or vegetable origin: The substance is classified into Division 4.2, PG II or III in UNRTDG (UN1361). Materials of mineral origin: No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on a LD0 value of >8000 mg/kg bw for rats (IUCLID (2000)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LD50 value is >3 mg/kg for rabbits (RTECS (2008), the original literature: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on results of "no irritating" in 4 tests with rabbits (one test was conducted according to OECD TG404) (IUCLID (2000)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Based on results of "no irritating" in 3 tests with rabbits (IUCLID (2002)), the substance was classified as "Not classified". Although there is a result of "irritating" in a human test (IUCLID (2002)), the details are not clear. It has been suggested that the fine grain may be irritating mechanically (HSDB (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a positive result in a rat alveolar cell HPRT gene mutation test by inhalation exposure and intratracheal administration (in vivo somatic cell mutagenicity test) (DFGOT vol. 18 (2002)), this positive result is considered not to indicate the germ cell mutagenicity of carbon black since it is thought to be induced by the polycyclic aromatic hydrocarbons present in the substance or by reactive oxygen species due to inflammation reaction. Classification was not possible due to lack of data from standard in vivo mutagenicity tests.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the classification of "Group 2B" in IARC and Category 2B in Japan Society For Occupational Health (JSOH), the substance was classified into Category 2. In a 24-month inhalation test in rats, the incidence of primary lung neoplasms was increased significantly and was dose related The types of neoplasms were identical and included benign adenomas, malignant adenocarcinomas, squamous-cell carcinomas, and adenosquamous carcinomas (EHC No. 171 (1996)). In a rat test, the 43-week and 86-week exposure groups had a lung tumour rate of 18% and 8%, respectively, with no tumours observed in the control group (IARC vol. 65 (1996)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is a report of behavioral somnolence as a symptom after oral administration to rats (15,400 mg/kg) (RTECS (2008)), the details are unknown, therefore, classification was not possible due to lack of sufficient data.
9 Specific target organ toxicity - Repeated exposure Category 1 (lung) Danger H372: Cause damage to organs through prolonged or repeated exposure (lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Numerous epidemiological tests for carbon black workers were conducted. In workers exposed for long term (10 years and more), the following symptoms characteristic of the lung occurred; cough, sputum, chronic bronchitis, lung function disturbances, pneumoconiosis, emphysema, disturbance of lung perfusion, obstructive disturbance of ventilation, bronchial hyper-reactivity and decrease in airway resistance and expiratory flow (IARC vol. 65 (1996)). In addition, it was reported that fine, diffuse changes were observed in the chest radiogram, and histological examination revealed deposits of carbon black particles and reticular fibrosis with associated emphysema (IARC vol. 65 (1996)). Since many changes or damages of the lung due to occupational exposure were reported as adverse effects of carbon black, the substance was classified into Category 1 (lung).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Classified into Not classified since it is suggested not to show the toxicity at the concentration of water solubility (insoluble (HSDB, 2009)) from its 72h-ErC50 >10000 mg/L for algae (Scenedesmus) (SIDS, 2006), its 24h-LC50 >5600 mg/L for Crustacea (Daphnia magna) (SIDS, 2006) and its 96h-LC50 >1000 mg/L for fish (Tribolodon hakonensis) (SIDS, 2006).
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification is not possible since it is non-water soluble and the acute toxicity has not been reported at or lower concentration of water solubility, further the behavior in water and bioaccumulative potential are unknown.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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