GHS Classification Result (Revision of the past classification result)

Chemical Name:n-Butyl acrylate
CAS:141-32-2

Result:
ID: 21B3014
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into Category 3 since flash point 41 degC (closed-cup) (Ullmanns (E) (2003)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2348).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since a stabilizer (MEHQ) is added to the commercial product and the stabilized product is classified into Class 3 in UNRTDG though there are chemical groups associated with self-reactive properties present in the molecules.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 267 degC (Hommel (1996)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on LD50 values of 3143, 3730, 4920, 6170, 6220, 8125 and 9050 mg/kg for rats (SIDS (2009)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on LD50 values of 2000, 3100, 5700 mg/kg (ECETOC JACC 27 (1994)), 2000 and 3024 mg/kg (SIDS (2009)) for rabbits, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (room temperature)
1 Acute toxicity (Inhalation: Vapours) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on LC50 values of 8.08 mg/L (1543 ppmV), 10.3 mg/L (1967 ppmV), 11.9 mg/L (2273 ppmV), and 13.3 mg/L (2541 ppmV) (SIDS (2009)) and 14.3 mg/L (2732 ppmV) (ECETOC JACC 27 (1994)) for rats, the substance was classified into Category 3 since 3 of 5 LC50 values are in this category. Saturated vapour pressure concentration of the test substance is 7193 ppmV under the saturated vapour pressure (5.45 mmHg = 0.727 kPa). Since the test concentration is lower than 90% of saturated vapour pressure concentration, the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas (ppmV) was adopted.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
When undiluted substance was applied to the skin of rabbits with an occlusive covering for up to 20-hour, moderate to strong erythema and edema were observed at 24-hour after application and the 20-hour exposure also caused weak necrosis (SIDS (2009)). However, the effects were reversible and much weaker 8 days after exposure. Based on a result of "irritating" (SIDS (2009)), the substance was classified into Category 2. Other rabbit tests resulted in results of "slightly irritating" or "no irritating" (SIDS (2009)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
When the undiluted substance was instilled into the eyes of 5 rabbits, no injury was observed in 1 rabbit and moderate or severe effects were observed in 4 rabbits (2 rabbits with iritis) (SIDS (2009)). In other rabbit tests, slight corneal cloudiness or moderately to severely damage was reported (SIDS (2009)). Based on the evaluation of "irritating" or "highly irritating" in the above tests, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In 2 guinea pig skin sensitizing tests (maximization test and Freund's complete adjuvant test), positive rates were 7/10 (70%) and 8/8 (100%), respectively, and conclusions of sensitizing were made (SIDS (2009)). A positive result was also obtained in a Local Lymph Node Assay (LLNA) in mice (SIDS (2009)). In humans, there are many case reports of positive responses in skin sensitization patch tests (SIDS (2002), DFGOT 5 (1993)). Since results of all animal tests using various methods and species are positive and many reports indicate skin sensitization of this substance in humans, the substance was classified into Category 1. As relevant information, the substance is classified into R43 in EU classification.
5 Germ cell mutagenicity Not classified - - - - Based on negative results in bone marrow chromosomal aberration tests by inhalation exposure to hamsters and rats (in vivo somatic cell mutagenicity tests) (ECETOC JACC 27 (1994)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames tests (SIDS (2009), ACGIH (7th, 2003), DFGOT vol. 16 (2001)), micronucleus tests (ECETOC JACC 27 (1994), SIDS (2009), ACGIH (7th, 2003)) and chromosomal aberration test (SIDS (2009)).
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC 71 (1999)), the substance was classified as "Not classified". As relevant information, the substance is classified into "A4" in ACGIH. In a 24-month inhalation test in rats, there was no increased frequency of any tumour type in any organ that could be related to the test substance (IARC 71 (1999)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Inhalation exposure to rats during organogenesis period caused embryo lethality, as evidenced by a dose-dependent increase in post-implantation loss at doses in which maternal animals showed a decrease in body weight gain (SIDS (2009)). In a developmental toxicity test by oral exposure to mice during organogenesis period, the percentage of resorptions and the number of fetuses with external and skeletal malformations and variations (cleft palate, exencephaly, open eyes, fused arch's) was significantly increased at doses in which maternal animals died or showed a decrease in body weight gain (SIDS (2009)). Based on the results of the rat and mouse tests, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In an acute inhalation toxicity test in rats by 4-hour exposure, spasmodically breathe and prone position were observed at 3.6 mg/L, and nasal secretion, noisy breathing and piloerection were additionally observed at 4.96 - 8.1 mg/L. Additional clinical signs at 12.1 - 16.0 mg/L were dyspnea, trembling and closed eyelids. Deaths occurred at 6.8 mg/L and higher concentrations (SIDS (2009)). In a second inhalation test (LC50: 8.08 mg/L), lungs were congested in victims and survivors had pneumonia (SIDS (2009)). In a third inhalation test (LC50: 13.3 mg/L), clinical signs included agitation, dyspnoea, hyperaemia of the nasal and ocular mucosa, pulmonary haemorrhages, pulmonary oedema, and emphysema (ECETOC JACC 27 (1994)). In an acute oral toxicity test, labored breathing and prone position were observed at a high dose level and autopsy of victims revealed hemorrhagic lungs (SIDS (2009)). Since these adverse effects on the lung and respiratory tract were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nasal cavity) Danger H372: Cause damage to organs through prolonged or repeated exposure (nasal cavity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a 13-week (6 hour/day) inhalation (vapour) test in rats, there was no adverse effect at dosing levels within the guidance value range (SIDS (2009)). In a 24-month (6 hour/day) inhalation test in rats (vapour, 0.086 - 0.773 mg/L), atrophy and hyperplasia of the olfactory epithelium were observed. Histological changes were dose-dependent and reported as slight atrophy of the neurogenic part of the olfactory epithelium to partial loss of the columnar cell layer and stratified reserve-cell hyperplasia (SIDS (2009), DFGOT vol. 12 (1999)). No changes were detected in the respiratory tract and lungs. Based on the data, the substance was classified into Category 1 (nasal cavity).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 2 from its 96h-LC50 = 2420 microg/L for fish (Oryzias latipes) (Initial Environmental Risk Assessment of Chemical Substances (Ministry of the Environment), Vol. 7, 2009).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified into Not classified since it is rapidly degradable (BOD degradation rate: 61.3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1975)) and low bioaccumulative potential is estimated (log Kow = 2.36 (PHYSPROP Database, 2009)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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