GHS Classification Result (Revision of the past classification result)

Chemical Name:Methyl iodine
CAS:74-88-4

Result:
ID: 21B3013
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - Information is available such as "Not combustible "(ICSC (J) (2004), (Hommel (1996)) and "flash point 1 degF (-17.2 degC)" (Chemical Risk Information Platform (CHRIP) (access on April, 2009)). The substance is classified into Classification not possible since it is considered that the substance does not burn continuously if ignited though it is classified into Category 2 (Flammable liquids) according to the GHS criteria from flash point and boiling point. Methyl bromide (gas), which is a similar compound, is generally classified as "Not combustible gas" (ISO-5145) though it is classfied into Category 1 (Flammable gases) according to the GHS criteria from the reported data of LEL, UEL.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 355 degC (GESTIS (Access on April. 2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to liquid (low boiling point) substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on LD50 values of 76 mg/kg bw (IARC vol. 41 (1986)) and 150 - 200 mg/kg bw (PATTY (5th, 2001)) for rats, the substance was classified into Category 3.
1 Acute toxicity (Dermal) Not classified - - - - Based on a LD50 value of >2000 mg/kg and no mortality at 2000 mg/kg for rabbits of both sexes (Test Data for Supporting Registration of Pesticides (2004), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on a LC50 value of 232 ppm/4h for rats (ACGIH (2001), DFGOT vol. 7 (1979), PATTY (5th, 2001)), the substance was classified into Category 2. Saturated vapour pressure concentration of the test substance was 532,894 ppm. Since the test concentration (232 ppm) was lower than 90% of saturated vapour pressure concentration (479,605 ppm), the classification criteria for gas (ppmV) was adopted.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on a result in a rabbit skin irritation test that no corrosive effect was observed and the primary skin irritation score was 4.88 after semi-occlusive application for 4-hour, the substance was judged to be "moderately irritating" (Test Data for Supporting Registration of Pesticides (2004), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)), the substance was classified into Category 2. As relevant information, the substance is classified into Xi; R37/38 in EU classification. For humans, there is a report that application of 1 mL to skin of volunteers for 1/2-hour produced erythematous reaction with vesicles 19-hour after application (IARC vol. 15 (1977)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
In a rabbit test, conjunctivitis was observed in all 6 rabbits at 1-hour after application and corneal opacity and iritis were noted in all 6 rabbits at 24-hour after application. At 21 days after application, conjunctivitis persisted in 4/6 rabbits and corneal opacity persisted in 2/6 rabbits (Test Data for Supporting Registration of Pesticides (2004)). Since some of the damage did not recover completely within 21 days, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In a guinea pig skin sensitizing test (Maximization test: US. EPA. OPPTS 870.2600), the positive rate was 5 - 15% (Test Data for Supporting Registration of Pesticides (2004)) and a result of "not sensitizing" was made (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Based on these information, the substance was classified as "Not classified".
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a mouse bone marrow chromosomal aberration test by intraperitoneal administration (in vivo somatic cell mutagenicity test) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008), Test Data for Supporting Registration of Pesticides (2004)), the substance was classified as "Not classified". As relevant information, there is a report of a positive DNA (covalent) binding test by oral or inhalation exposure to rats (in vivo somatic cell genotoxicity test) (IARC 71 (1999)), and, from in vitro mutagenicity tests, there are reports of negative or positive Ames tests and mouse lymphoma gene mutation tests (IARC 71 (1999), Test Data for Supporting Registration of Pesticides) and positive HPRT mutation tests and chromosomal aberration tests using CHO cells (IARC 71 (1999), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)).
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC vol. 71 (1999)), the substance was classified as "Not classified". However, in a 24-month inhalation test in rats and a 18-month oral test in mice, a significant increase or tendency of increase in the incidences of follicular cell adenoma and carcinoma in the thyroid were observed in the high dose groups (Test Data for Supporting Registration of Pesticides (2006)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a two-generation reproductive toxicity test in rats by inhalation exposure, there were no reproductive effects (Test Data for Supporting Registration of Pesticides (2004)). In a developmental toxicity tests in rats by inhalation exposure on gestation days 6 through 19, no treatment-related effects on fetuses including teratogenicity were observed at doses in which parental animals showed decreases in body weight gain and food consumption (Test Data for Supporting Registration of Pesticides (2004)). However, in a developmental toxicity test in rabbits by inhalation exposure on gestation days 6 through 28, decreased maternal body weight gain and decreased number of live fetuses with increased postimplantation loss were observed (Test Data for Supporting Registration of Pesticides (2004)). In a second rabbit test, it was concluded that exposure during late gestational period (days 23 - 26) might elicit developmental toxicity (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Based on these information, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was reported that in survivors of acute intoxications with the substance, neurological lesions regress very slowly and frequently, the intoxication is followed by a phase with psychic disorders such as confusion, hallucinations, delusions and paranoia which can persist for years (DFGOT vol. 7 (1979)). Based on this information, the substance was classified into Category 1 (nervous system). In an oral test in mice, a decrease in alertness, decreased locomotor activity, prone position, staggering gait, drowsiness, decreased responsiveness, dorsal position, gait difficulty and bradypnea were observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). In an inhalation test in rats, increase in repetitive movement of mouth and jaw, shallow respiration, sitting position with dropped head, ptosis, salivation, gasping, hunchback position, gait disturbance, decreases in ambulatory movement and locomotor activity were observed (Test Data for Supporting Registration of Pesticides (2004)). These signs suggest an effect on the nervous system.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (thyroid) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (thyroid)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Numerous cases of methyl iodide intoxications by occupational exposure were reported (ACGIH (2001), IARC 41 (1986), PATTY (5th, 2001), HSDB (2005)). In these reports, visual disturbance, dizziness, tremors, lethargy, coma, and slurred speech are reported as characteristic symptoms. In addition, psychiatric disorders which may require time to recover was reported (IARC 41 (1986), PATTY (5th, 2001)). In a 2-year inhalation test in rats, clinical signs such as decreased locomotor activity, decreases in muscular coordination and balance, muscular spasm and tremors were noted. Based on the data, the substance was classified into Category 1 (nervous system). At all treated doses (23.6 - 221.6 mg/kg) in a 90-day oral test in mice (Test Data for Supporting Registration of Pesticides (2004)) and at a dose of 12 mg/kg in a 14-week oral test in dogs (Test Data for Supporting Registration of Pesticides (2004)), and at a dose of 60 ppm (vapour, 0.348 mg/L) in a 24-month inhalation test in rats (Test Data for Supporting Registration of Pesticides (2004)), histopathological findings in the thyroid such as thinning, hypertrophy, hyperplasia and cytoplasmic vacuolization of thyroid follicular cell were noted. Since these findings in the thyroid were observed in more than one animal species at dose levels within the guidance value range for Category 2, the substance was classified into Category 2 (thyroid).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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