GHS Classification Result （Revision of the past classification result）

Chemical Name：Trichloroacetic acid
CAS：76-03-9

Result：
ID: 21B3011
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC (J) (1998), Hommel (1996))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is >110 degC (Gangolli (vol. 7, 2nd, 1999)) exceeding 70 degC.
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (J) (1998), Hommel (1996))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen and chlorine which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available. Information is available that the substance corrodes iron, zinc and aluminum (HSDB (2007)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on a LD50 value of 3320 mg/kg for rats (ACGIH (2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of >2000 mg/kg for rats (SIDS (access on April. 2009)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Although LC50 values were >4800 ppm (32.2 mg/L) for rats, rabbits, guinea pigs and cats (SIDS (access on April. 2009)), the details were not clear and the original literature can not be confirmed. Classification was not possible due to lack of data. (Since the test was considered to be conducted at higher than the saturated vapour pressure concentration, the LC50 values correspond to "Not classified").
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a result of corrosive to the skin of rabbits (SIDS (access on April. 2009)). In another rabbit test, there are results of "slight irritation" after application of 0.21 mg and "severe irritation" after application of 3.5 mg (BUA 167 (1995)). Additionally, it has been reported that depending upon concentration and duration of contact, the substance can produce burns (ACGIH (2001)). Based on these information and a pH of < 1 (900 g/L, 20 degC) (IUCLID (2000)), the substance was classified into Category 1. As relevant information, the substance is classified into C; R35 in EU classification.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		There is a report that severe and extensive loss of epithelium and endothelium, infiltration and hemorrhage about the limbal vessels occurred in a rabbit test (ACGIH (2001)) and a report that severe injury of the eye was caused after application of a 30% solution to rabbit eyes which was not completely reversible within 21 days. The Modified Maximum Average Score (MMAS) was calculated to be 106 at 24, 48 and 72-hour, respectively, after application (ECETOC TR48 (1998)). Based on these information and a pH of <1 (900 g/L, 20 degC), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there is a report of not skin sensitizing in a guinea pig maximization test (IUCLID (2000), BUA 167 (1995)), the data is reported in a document in List 2 and the details are unknown. Classification was not possible due to lack of sufficient data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive results in a bone marrow micronucleus test and a chromosomal aberration test by intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (IARC vol. 63 (1995), IRIS (2003)) and in hepatic cell DNA damage tests by oral administration to mice and rats (in vivo somatic cell genotoxicity test) (IARC vol. 63 (1995), IRIS (2003)), the substance was classified into Category 2. As relevant information, from in vitro mutagenicity tests, there are negative Ames tests (ACGIH (2001), IARC vol. 63 (1995), IRIS (2003), NTP DB (access on 2009)).
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC vol. 84 (2004)), the substance was classified as "Not classified". As relevant information, the substance is classified into "C" in EPA (IRIS (2003)) and "A3" in ACGIH (ACGIH (7th, 2001)). There is a report that increases in the incidence of liver tumours (adenomas and carcinomas) were observed in mice but not in rats following long-term oral exposure to the substance (IARC vol. 84 (2004)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a developmental toxicity test by oral administration of the substance to rats during organogenesis period, dose-dependent increases in percent of resorbed implants per litter and reductions in weight and length of live fetuses were observed at dose levels in which parental general toxicity was noted (weight gain was reduced). Additionally, cardiovascular and skeletal malformations were found at higher dose levels (ACGIH (2001)). Based on the report, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a report that animals poisoned by oral exposure quickly passed into a state of narcosis or seminarcosis. Within 36-hour, the esposed animals either recovered completely or died (ACGIH (2001)). Based on this information the substance was classified into Category 3 (narcotic effects). Although there is a report that breathing the substance can irritate the lungs causing coughing and/or shortness of breath; higher exposures can cause a build-up of pulmonary edema (HSFS (2004), SITTIG (5th, 2008), ICSC (J) (1998)), these findings were not used as the basis of classification since the information is found in documents in List 3 and lack detailed data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In both male rats administered up to 350 - 785 mg/kg/day of the substance in their drinking water for 90 days (ACGIH (2001), IARC vol. 63 (1995)) and male mice administered up to 500 mg/kg/day in their drinking water for 10 weeks (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2006)), no significant toxic findings were noted. Since these tests were conducted using males only and the adequacy of the examination parameters is questionable, classification was not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified into Not classified from its 96h-LC50 = 2000 mg/L for fish (Fathead minnow) (SIDS, 2003) and 48h-EC50 = 2000 mg/L for Crustacea (Daphnia magna) (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No reliable chronic toxicity data available. Classified into Not classified since its 96h-LC50 = 2000 mg/L for fish (Fathead minnow) (SIDS, 2000), 24h-EC50 = 2000 mg/L for Crustacea (Daphnia magna) and it is not non-water soluble (Water solubility = 54600 mg/L, PHYSPROP Database, 2009).
12 Hazardous to the ozone layer Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information