GHS Classification Result （Revision of the past classification result）

Chemical Name：Ethyl acetate
CAS：141-78-6

Result：
ID: 21B3008
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 2 since flash point -4 degC (ICSC (1997)) is <23 degC and initial boiling point 77 degC (ICSC (J) (1997)) is >35 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 427 degC (ICSC (J) (1997)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50 values of 4940 mg/kg (PATTY (5th, 2001)), 5600 mg/kg (ACGIH (2001)), 10100 mg/kg (DFGOT vol. 12 (1999)) and 11000 mg/kg (PATTY (5th, 2001)) for rats, the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on no mortality at 18000 mg/kg after 24-hour occlusive application for rabbits (DFGOT vol. 12 (1999)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on LC50 values of 16,000 ppm (4-hour equivalence: 19,600 ppmV) (ACGIH (2001)), 14,640 mL/m3 (13,176 g/m3: 3658 ppmV) (DFGOT vol. 12 (1999)) and 16,000 ppm (4-hour equivalence: 13,856 ppmV) (ACGIH (2001)) for rats, the substance was classified into Category 4. Since saturated vapour pressure concentration was 123,289 ppmV, the classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on a result of "not irritating" in a rabbit test where the irritation score was 1 (max 10) following open application of 0.01 mL of the substance to the skin for 24-hour (IUCLID (2000)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on a report of a Draize test using 4 rabbits where corneal opacity (4/4) was resolved within 2 days, iritis (1/4) was resolved within 2 days, conjunctivae redness, chemosis and discharge (4/4) disappeared by 7 days after application of 0.1 mL to the eyes, and the MMAS (Modified Maximum Average Score) at 24, 48 and 72-hour after application was calculated to be 15.0 (ECETOC TR48 (1998)), the substance was classified into Category 2B. As relevant information, the substance is classified as Xi; R36 in EU classification.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Based on a result of "not sensitizing" in a guinea pig maximization test (OECD TG406) (IUCLID (2000)) and a result of "not sensitizing" in a human maximization test using twenty-five volunteers (DFGOT vol. 12 (1999)), the substance was classified as "Not classified". As relevant information, there are reports of 3 cases of suspected sensitization to ethyl acetate. As a result of the unclear causality in some cases and the small number of cases, the sensitizing potential of ethyl acetate must be considered to be questionable (DFGOT vol. 12 (1999)).
5 Germ cell mutagenicity Not classified - - - - Based on negative results in bone marrow micronucleus tests by intraperitoneal or oral administration to mice and hamster (in vivo somatic cell mutagenicity tests) (DFGOT vol. 12 (1999), IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames tests, hamster fibroblast chromosomal aberration tests, and CHO cell SCE assays.
6 Carcinogenicity Classification not possible - - - - Although there is a mouse test by intraperitoneal injection for 8 weeks (IUCLID (2000)), classification was not possible due to lack of sufficient data.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was reported that exposure of volunteers for 4-hour to 400 ppm of the substance led to slight irritation of the eyes, nose and throat (DFGOT vol. 12 (1999), ACGIH (2001)). There is a report that the inhalation exposure to cats and mice and the oral exposure to rabbits caused narcotic effects at dose levels of equal to or less than the LD50 value. The effects are transient (ACGIH (2001), IUCLID (2000)). Based on the data, the substance was classified into Category 3 (respiratory tract irritation, narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 90-day oral test in rats, the NOAEL was 900 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2008)). In a 13-week inhalation test in rats, clinical signs such as reduced reaction to stimulation were observed at concentrations of 2700 mg/m3/4h (9.73 mg/L/4h, vapour) and higher, but there was no exposure-related change in the functional observational battery. The NOAEL was reported to be 1260 mg/m3/4h (1.2 mg/L/4h) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2008)). Since the NOAELs exceed the upper limit of the guidance value range, the substance corresponds to "Not classified" with oral and inhalation exposure. However, classification was not possible due to lack of data with dermal exposure. As relevant information, there is a human report that in a shoe factory where the occupational exposure concentrations was 1560 ppm, seven employees were found to have unspecific symptoms such as irritation and four individuals showed bronchoconstriction (DFGOT vol. 12 (1999)). This report was not used as the basis of classification since the individuals were exposed to a mixture of substances, not the substance alone.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified into Not classified from its 96h-LC50 = 230 mg/L for fish (Fathead minnow) (SIDS, 2008, etc) and 24h-LC50 = 2500 mg/L for Crustacea (Daphnia magna) (SIDS, 2008).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (Water solubility = 80000 mg/L (PHYSPROP Database, 2009)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information