NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：Hydrogen chloride
CAS：7647-01-0

Result：


ID:	21B3004
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Gas (GHS definition)
2	Flammable gases （including chemically unstable gases）	Not classified	-	-	-	-	Not combustible gas (Hommel (1996))
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not classified	-	-	-	-	The substance is classified into Division 2.3 in UNRTDG (UN1050), Subsidiary risk 8, but not into Division 5.1 (Oxidizing substances) in UNRTDG.
5	Gases under pressure	High pressure liquefied gas		Warning	H280: Contains gas under pressure; may explode if heated	P410+P403: Protect from sunlight. Store in a well-ventilated place.	The substance is classified into Division 2.3 in UNRTDG (UN1050). Critical temperature is 51 degC (Hommel (1996)) between -50 degC and 65 degC.
6	Flammable liquids	Not applicable	-	-	-	-	Gas (GHS definition)
7	Flammable solids	Not applicable	-	-	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	-	-	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	-	-	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	-	-	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on LD50 values of 238 - 277 mg/kg and 700 mg/kg for rats (SIDS (2009)), the lower value was adopted and the substance was classified into Category 3.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on a LD50 value of >5010 mg/kg for rabbits (SIDS (2009)), the substance was classified as "Not classified".
1	Acute toxicity （Inhalation: Gases）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on LC50 values of 4.2, 4.7 and 283 mg/L (4-hour equivalence: 1411, 1579 and 95,083 ppm, respectively) for rats (SIDS (2009)), the lowest value was adopted and the substance was classified into Category 3.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a LC50 value (aerosol) of 1.68 mg/L/1h (4-hour equivalence: 0.42 mg/L) for rats (SIDS (2009)), the substance was classified into Category 2.
2	Skin corrosion/irritation	Category 1		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	In a rabbit skin irritation test, application for 1 - 4-hour caused corrosion at higher concentrations (SIDS (2009)). Skin irritation and ulceration with fur discoloration occurred in mice and rats dermally exposed for 5 - 30 minutes (SIDS (2009)). In human experiments, there are reports that contact caused slight to strong irritation, or ulceration and severe burns to the skin (SIDS (2009)). Based on these data, the substance was considered to have corrosive properties, and was classified into Category 1.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	The substance was classified as a skin corrosive substance. In eye damage and irritation tests, solutions of the substance, hydrochloric acid, was used as a test substance. In animal tests including rabbit tests, high irritation, damage and corrosion to eyes have been reported (SIDS (2002)). For humans, the concentrated solution can cause permanent damage and loss of sight (SIDS (2002)). Based on these data, the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into C; R34.
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	Since the substance is on the sensitizing chemical substance list by Japanese Society of Occupational and Environmental allergy, the substance was classified into Category 1. There is a report that after exposure to a cleaning product that contained hydrogen chloride, the subject developed bronchospasm and still had marked asthma symptoms 1 year after exposure that were triggered by exercise and inhalation of trivial concentrations of irritants (ACGIH (2003)).
4	Skin sensitization	Not classified	-	-	-	-	A guinea pig maximization test and a mouse ear swelling test demonstrated negative results (SIDS (2009)) for the substance. In a human test using fifty volunteers, none gave a positive reaction in a challenge application, 10 ? 14 days after the final induction application (SIDS (2009)). The substance was classified as "Not classified".
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test and a positive result (which is considered to be an artifact due to the low pH) chromosome aberration test (SIDS (2009)).
6	Carcinogenicity	Not classified	-	-	-	-	Based on the classifications of "Group 3" in IARC (1992) and "A4" in ACGIH (2003), the substance was classified as "Not classified". As relevant information, no evidence of carcinogenicity was observed in rat and mouse carcinogenicity tests (SIDS (2009)). Epidemiologic tests did not suggest an association between exposure to hydrogen chloride and cancer development (IARC 54 (1992), PATTY (5th, 2001)).
7	Reproductive toxicity	Classification not possible	-	-	-	-	In rat and mice tests by exposure during gestation period, there were no adverse effects on fetal development, however, classification was not possible since there are no data for effects on sexual function and fertility by exposure before mating or gestation.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)		Danger	H370: Causes damage to organs (respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In humans, inhalation exposure caused symptoms such as dyspnea, laryngitis, bronchitis, bronchoconstriction, pneumonia and edema. Inflammation and necrosis of the upper respiratory tract and pulmonary edema have also been reported (DFGOT vol. 6 (1994), PATTY (5th, 2001), IARC 54 (1992), ACGIH (2003)). In animal tests, toxic effects with morphological change of the lung and bronchus such as bronchitis with mucosal necrosis, pulmonary edema, hemorrhage, and thrombus were observed at dose levels within the guidance value range for Category 1 (ACGIH (2003), SIDS (2009)). Based on the information for humans and animals, the substance was classified into Category 1 (respiratory system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (tooth, respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (tooth, respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There are 2 or more reports for humans in which repeated exposure caused tooth damage by erosion (SIDS (2002), EHC 21 (1982), DFGOT vol. 6 (1994), PATTY (5th, 2001)). Additionally, an increase in the frequency of chronic bronchitis was reported (DFGOT vol. 6 (1994)). Based on the information, the substance was classified into Category 1 (tooth, respiratory system).
10	Aspiration hazard	Not applicable	-	-	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 from its 48h-EC50 = 0.492 mg/L for Crustacea (Daphnia magna) (SIDS, 2005), etc.
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Classified into Not classified since the toxicity is mitigated in environmental water by buffer action though it is considered to be a factor of toxicity that water solution becomes strongly acidic.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）