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GHS Classification Result

Chemical Name：Bismuth (III) oxide
CAS：1304-76-3

Result：


ID:	21A3765
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Classified into Not classified since the substance is non-combustible solid (GESTIS (access on Oct. 2009)).
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Classified into Not classified since the substance is judged not to spontaneously ignite on contact with room temperature air from the description of "Non combustible solid" (GESTIS (access on Oct. 2009))
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Classified into Not classified since the substance is non-combustible solid (GESTIS (access on Oct. 2009)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	The substance is considered not to cause dangerous reaction with water from the information that it is practically insoluble in water (Merck (14th, 2006)) though it contains metalloids (Bi).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	-	-	-	-	Classification is not possible since no data are available though the substance contains oxygen which is chemically bonded to Bi.
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	No data available. As relevant information, a LD50 value is 4 mg/kg for rats (RTECS (2007)). [For health hazards, refer also to other bismuth compounds].
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Although there is information that chromosome aberrations (including gaps) were observed in an oral rat bone marrow chromosomal aberration test (in vivo somatic cell mutagenicity test) (PATTY (5th, 2009)), classification was not possible since the details are unclear.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, kidney, articulation of the bone)		Danger	H370: Causes damage to organs (nervous system, kidney, articulation of the bone)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was reported that common toxic effects that were attributed to bismuth and bismuth compounds in humans are encephalopathy, nephropathy, osteoarthropathy, gingivitis, stomatitis and colitis, and inorganic bismuth compounds cause neurotoxicity (PATTY (5th, 2001)). Additionally, there is a report that clinical manifestations of acute bismuth intoxication are similar to those caused by mercury and lead: neurological abnormalities which include encephalopathy, and renal dysfunction with nephrotic syndrome (PATTY (5th, 2001)). Based on this information, the substance was classified into Category 1 (nervous system, kidney, bone, joint).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, articulation of the bone, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, articulation of the bone, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since it was reported that common toxic effects that were attributed to bismuth and bismuth compounds in humans are encephalopathy, nephropathy, osteoarthropathy, gingivitis, stomatitis and colitis, and inorganic bismuth compounds cause neurotoxicity (PATTY (5th, 2001)), the substance was classified into Category 1 (nervous system, bone, joint, kidney). In addition, there is a report that the symptoms of chronic toxicity in humans consist of decreased appetite, rheumatic pain, diarrhea, fever, foul breath, gingivitis and dermatitis (HSDB (2002)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）