GHS Classification Result

Chemical Name：Indium phosphide
CAS：22398-80-7

Result：
ID: 21A3757
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Classified into Not classified since the substance is considered to be stable against water from the information that it slightly dissolves in acid solutions (Lide (88th, 2008)) though it contains metals (In).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on no mortality at 5000 mg/kg in mice (NTP TR499 (2001)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - In a mouse peripheral blood micronucleus test by 90-day inhalation exposure (in vivo somatic cell mutagenicity test), no significant increase in micronucleated normochromatic erythrocytes was noted in males or females. A significant increase in micronucleated polychromatic erythrocytes was observed in the highest dose group of females, but this effect was not observed in any group of males (NTP DB (access on Oct. 2009)). Classification was not possible.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the classification of "Group 2A" in IARC (IARC 86 (2006)), the substance was classified into Category 1B. In rat and mouse 105-week inhalation tests (concentrations of 0, 0.03, 0.1 or 0.3 mg/m3, animals in the 0.1 and 0.3 mg/m3 groups were exposed for approximately 22 weeks and evaluated at 2 years), there was clear evidence of carcinogenic activity in both rats and mice based on increased incidences of benign and malignant neoplasms of the lung and pheochromocytoma of the adrenal gland in rats, and increased incidences of benign and malignant neoplasms of the lung and liver in mice (NTP TR499 (2001)).
7 Reproductive toxicity Classification not possible - - - - In inhalation developmental toxicity tests in rats and mice exposed during the organogenesis period, a concentration-related increase in lung weights was observed in rats, and early deaths and reduced body weight gain were observed in mice of the high dose (100 mg/m3) group as general toxicity in parental animals. At this dose level, there was no fetal toxicity, malformation, or effects of exposure on any developmental toxicity parameter (NTP TR499 (2001)). Classification was not possible due to lack of data for effects on sexual function and fertility of parental animals exposed before mating.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Based on a report that there was no deaths or toxic effects in rats administered orally at dose levels of 1000 - 5000 mg/kg (NTP TR499 (2001)), the substance corresponds to "Not classified" with oral exposure. Classification was not possible due to lack of data with other exposure routes (inhalation and dermal). In a rat intratracheal test, strong inflammatory lesion in the lung was observed at dose levels of 1 mg/kg and higher, and inflammatory lesion, alveolar epithelial desquamation and intraalveolar effusion in the lung were observed at a dose level of 62.0 microg/kg (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2007)). These findings were not used as the basis of classification due to intratracheal exposure.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, hematopoietic system), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, hematopoietic system)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 14-week inhalation tests in rats and mice (0.0011 - 0.1 mg/L, dusts), the lungs of all exposed animals had discoloration and were enlarged, inflammatory and proliferative lesions consisted of alveolar proteinosis, chronic inflammation, interstitial fibrosis and alveolar epithelial hyperplasia occurred (the effects in rats were more serious than those in mice). The substance caused inflammation at the base of the epiglottis of the larynx and hyperplasia of the bronchial lymph nodes (NTP TR499 (2001)). In addition, exposure to the substance affected the circulating erythroid mass, and induced a microcytic erythrocytosis consistent with bone marrow hyperplasia and hematopoietic cell proliferation of the spleen (NTP TR499 (2001)). Since these findings were observed at exposure concentrations within the guidance value range for Category 1 or 2, the substance was classified into Category 1 (respiratory system, hematopoietic system). Hepatocellular necrosis was suggested by increased serum activities of alanine aminotransferase and was confirmed microscopically at a concentration of 0.1 mg/L (within the guidance value range for Category 2) in the 14-week inhalation test in rats, therefore, the substance was classified into Category 2 (liver). Additionally, there is a report that the substance caused obvious testicular damage in a test where hamsters were observed for approximately two years following intratracheal instillations of 3.0 mg/kg. Decreases in male reproductive organ weight and caudal sperm count, and severe histopathologic changes in the testes were also found (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2007)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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