NITE - Chemical Management Field

GHS Classification Result

Chemical Name：4-Methoxyfuro［3,2-g］chromen-7-one, (alias Bergapten)
CAS：484-20-8

Result：


ID:	21A3742
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	The substance contains oxygen which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on a LD50 value of >30000 mg/kg for rats (IARC vol. 40 (1986)), the substance was classified into "Not classified".
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available. The substance is on the Frosch allergen list as a photosensitizer (FROSCH, TEXTBOOK OF CONTACT DERMATITIS). The substance was classified into Category 1.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	There is a report of a positive intraperitoneal mouse bone marrow chromosomal aberration test (in vivo somatic cell mutagenicity test) (NTP DB (access on Oct. 2009)). From in vitro mutagenicity tests, there are reports of positive Ames tests, Chinese hamster ovary cell SCE tests and chromosomal aberration tests (NTP DB (access on Oct. 2009)), human cell chromosomal aberration tests and DNA binding tests (IARC vol. 40 (1986)). The substance was classified into Category 2. As relevant information, there are reports of negative intraperitoneal mouse micronucleus tests using bone marrow and peripheral blood (in vivo somatic cell mutagenicity tests) (NTP DB (access on Oct. 2009)).
6	Carcinogenicity	Category 1B		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the classification of "Group 2A" in IARC (IARC suppl. 7 (1987)), the substance was classified into Category 1B. In animal tests, skin tumours (mainly papillomas) was observed when mice received topical application and simulated solar irradiation for 37 weeks (IARC vol. 40 (1986)) and squamous-cell carcinomas invading the dermis and cartilage was observed when mice received topical application plus UV (wavelengths <340 nm) irradiation for 23 weeks (IARC vol. 40 (1986)). Epidemiologically, it was reported that "keratomas" or "epitheliomas" of the skin were found in exposed workers in the bergamot oil (containing the substance as an ingredient) production industry. However, there is a report that a clear causal relationship was not confirmed (IARC vol. 40 (1986)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a report that there was a dose-dependent increase in fetal abnormalities at dose levels at which there was maternal toxicity (decreased weight gain; only 50% of dam gave birth to living pups) when rabbits were administered orally during organogenesis period (IARC vol. 40 (1986)), the substance was classified into Category 2. As relevant information, there was maternal toxicity (decreased weight gain, fewer litters), but no significant increase in anomalies in surviving fetuses when rats were administered orally during organogenesis period (IARC vol. 40 (1986)).
8	Specific target organ toxicity - Single exposure	Category 1 (skin)		Danger	H370: Causes damage to organs (skin)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Application of 4 - 200 microg/2.5 cm2 to human skin and irradiation with UVA induced erythema 22 minutes to 36-hour after irradiation, followed by marked pigmentation seven to 15 days later (IARC vol. 40 (1986)). Administration of an oral dose of 8.6 mg/kg (within the guidance value range for Category 1) to guinea-pig and exposure to UV radiation induced marked erythema (IARC vol. 40 (1986)). Based on these reports, the substance was classified into Category 1 (skin).
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There is a report that hepatomegaly, necrosis and hepatic inflammation occurred at a dose level of 19 mg/kg (90-day equivalence) (administration for 28 days) in a dog oral test (IARC vol. 40 (1986)). Since these effects were observed at a dose level within the guidance value range for Category 2 and the liver was regarded as a target organ, the substance was classified into Category 2 (liver). As relevant information, there is a report that in a rat 1-year oral test, a dose-dependent (70, 280, 560 mg/kg) perimedullary connective tissue proliferation of the adrenals was observed in females (IARC vol. 40 (1986)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）