GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Sodium perborate tetrahydrate
CAS：10486-00-7
Result：
| ID: | 21A3724 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | No data are available though there are chemical groups (-O-O-) associated with explosive properties present in the molecules. However, the substance is judged not to be classified into upper class "Explosives" since the substance is classified into Division 5.1 in UNRTDG (UN1479: OXIDIZING SOLID, N.O.S.) (ICSC (J) (2004)), further monohydrate is classified into Division 5.1, PG III in UNRTDG (UN3377) and is considered to be a practical oxidizing substance. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not combustible (ICSC (J) (2004)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | No data are available though there are chemical groups (-O-O-) associated with explosive properties present in the molecules. However, the substance is judged not to be classified into upper class "Self-reactive substances and mixtures" since the substance is classified into Division 5.1 in UNRTDG (UN1479: OXIDIZING SOLID, N.O.S.) (ICSC (J) (2004)), further monohydrate is classified into Division 5.1, PG III in UNRTDG (UN3377) and is considered to be a practical oxidizing substance. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible (ICSC (J) (2004)) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (ICSC (J) (2004)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | The substance is considered to be stable against water since data are available that water solubility is 2.3 g/100 mL (20 degC) (ICSC (2004)) though it contains metals (Na) and metalloids (B). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. Information is available that the substance is "Strong oxidizing agent (HSDB (2006)) and "Reacts with combustible or reducing substances" (ICSC (J) (2004))". It is classified into Division 5.1, PG III in UNRTDG (UN3377: SODIUM PERBORATE MONOHYDRATE). From the above, GHS Classification is not applicable though the substance is judged to be oxidizable. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on LD50 values of 2100 mg/kg and 2250 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS classification (correspond to Category 5 in GHS classification). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Although a LC50 value was >0.074 mg/L as dust (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)), the exposure period was not clear. Classification was not possible since determination of category was impossible. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on results of "non-irritating" in 4-hour application skin irritation tests with rabbits and guinea pigs (PATTY (5th, 2001)), the substance was classified as "Not classified". |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
In a rabbit eye irritation test (OECD TG405), cornea opacity, iritis, conjunctiva redness, chemosis and discharge were observed and cornea opacity persisted up to day 21 in 4/6 rabbits. The MMAS (Modified Maximum Average Score) was 30.5 (ECETOC TR48 (1998)). Additionally, an another rabbit eye irritation test resulted in "severe irritation" (PATTY, (5th, 2001), and the substance is classified into R41 in EU classification (EU-Annex I (Access on Sep. 2009)). Based on these information, the substance was classified into Category 1. As relevant information, the effects are alleviated by dilution, the diluted substance was reported to be "not irritating" or "slightly irritating" (PATTY (5th, 2001), ATSDR (2007)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is a report that parental toxicity, increased embryo resorptions, and cardiovascular and skeletal malformations were observed at a limit dose level when sodium perborate tetrahydrate was administrated to rats (Birth Defects (3rd, 2000)). Since these malformations were observed at dose levels at which toxicity was manifested in parental animals and the substance is classified into Repr. Category 2; R61 and Repr. Category 3; R62 in EU classification (EU-AnnexⅠ (access on Aug. 2009)), the substance was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data. There is a report that in a 28-day test in rat given at an oral dose of 1000 mg/kg/day (90-day equivalence: 311 mg/kg/day), histological changes in the stomach were observed that are probably attributable to the formation of hydrogen peroxide in the stomach (PATTY (5th, 2001)). In addition, there is a report that repeated oral use as a mouthwash or the ingestion of tablets and powders marketed as denture cleansers has caused injuries (HSDB (2006)). This information is not used as the basis of classification for specific target organ toxicity since they are considered to be effects by site of contact. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 2 from its 48h-EC50 = 6.98 mg/L for Crustacea (Ceriodaohnia dubia) (AQUIRE, 2010) |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2 since its acute toxicity is Category 2 and the behavior in water is unknown as it is inorganic compound. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |