GHS Classification Result

Chemical Name：tert-Butyl acrylate
CAS：1663-39-4

Result：
ID: 21A3723
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 2 since flash point 10 degC (closed-cup) (IUCLID (2000)) is <23 degC and initial boiling point 121 degC (IUCLID (2000)) is >35 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance, which contains a stabilizer (hydroquinone monomethy ether 100 ppm) and is classified into Class 3, PG III in UNRTDG (UN2348), is distributed though there is unsaturated bond (acrylic acid) present in the molecule.
9 Pyrophoric liquids Not classified - - - - Classified into Not classified since auto-ignition point is 385 degC (Hommel (1996)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine, or these atoms are chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 1047 mg/kg bw (SIAR Dossier (2005)) and 1056 mg/kg bw (IUCLID (2000)) for rats, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of >4000 mg/kg bw for rats (SIAR Dossier (2005)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LC50 value of 7 mg/L/4h (1336 ppmV) for rats (SIAR Dossier (2005)), the substance was classified into Category 3. Since saturated vapour pressure concentration is 22,369 ppm (117 mg/L) based on vapour pressure of 22.66 hPa at 25.7 degC (SIAR Dossier (2005)), the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas was adapted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Since there is a report that moderate erythema and slight edema was caused at 24-hour but only scaling was observed 8 days after application in a rabbit skin irritation test (SIAR Dossier (2005)), and that the substance was "slightly irritating" (SIAR Dossier (2005)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, in EU classification, the substance is classified into Xi: R37/38.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since there is a report that slight erythema and slight edema were observed 1-hour after application and only a marginal erythema was detected after 24-hour, but no effects were seen 8 days after the application (SIAR Dossier (2005)), the substance was concluded to be "slightly irritating" (SIDR Dossier (2005)). The substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a report that 4/10 animals were sensitized in a guinea pigs skin sensitization test (Maximization Test) (SIAR Dossier (2005)), the substance was classified into Category 1. As relevant information, the substance is classified into R43 in EU classification.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity test) (SIAR Dossier (2005)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (SIAR Dossier (2005) and IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Not classified - - - - In a combined 15-week subchronic inhalation toxicity test with a reproduction/developmental toxicity screening test in rats, significant systemic toxicity including mortality was observed in dams at a high dose level. Whereas the capability to cohabitate and to generate offspring were not affected at this dose level, the pre- and postnatal development of offspring was significantly impaired. The impaired postnatal development of the offspring was the consequence of an insufficient maternal care in the dams. So that means probably secondary to the marked maternal systemic toxicity (SIAR Dossier (2005)). Additionally, local effects, systemic toxicity, impairment of fertility and pre- and postnatal toxicity were not observed at the lower concentrations (SIAR Dossier (2005)). Based on this information, the substance was considered not to have adverse effects on sexual functions, fertility or development of offspring and was classified as "Not classified".
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a combined 15-week subchronic inhalation toxicity test with a reproduction/developmental toxicity screening test in rats, the concentration of 180 ppm (0.956 mg/L, 6 hr/day, 5 day/week) showed slight irritation to eyes and upper respiratory tract as well as impairment of body weight development in both sexes, mild impairment of renal function in the males, and reduced general state in both sexes. Two pregnant female animals in the group died. Both animals exhibited atrophy in the lymphoid tissues of spleen and thymus. Additionally, erosion/ulcer in the mucosa of the glandular stomach was observed in one animal (SIAR Dossier (2005)). Since repeated inhalation exposure of lower concentrations caused respiratory tract irritation, it is assumed that single exposure also causes respiratory tract irritation. The substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (systemic toxicity) Warning H373: May cause damage to organs through prolonged or repeated exposure (systemic toxicity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a combined 15-week subchronic inhalation toxicity test with a reproduction/developmental toxicity screening test in rats, the concentration of 180 ppm (0.956 mg/L, 6 hr/day, 5 day/week) showed slight irritation to eyes and upper respiratory tract as well as impairment of body weight development in both sexes, mild impairment of renal function in the males, and reduced general state in both sexes. Two pregnant female animals in the group died. Both animals exhibited atrophy in the lymphoid tissues of spleen and thymus. Additionally, erosion/ulcer in the mucosa of the glandular stomach was observed in one animal (SIAR Dossier (2005)). Additionally, it was reported that the test compound evoked marked systemic toxicity including mortality in pregnant and lactating female rats at the high dose level (180 ppm) (SIAR Dossier (2005)). Based on the report, the substance was classified into Category 2 (systemic toxicity).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 24h-EC50 = 42 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its bioconcentration potential is estimated to be low (LogKow = 2.09, KOWWIN) though the acute toxicity is Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information