GHS Classification Result

Chemical Name：Sodium perborate
CAS：7632-04-4

Result：
ID: 21A3722
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - The substance is classified into Division 5.1 (Oxydizing substances), PG II in UNRTDG (UN3247) though there are chemical groups (-O-O-) associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (room temperature)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (room temperature)
7 Flammable solids Not classified - - - - Information is available that sodium perborate tetrahydrate (10486-00-7) is not combustible (ICSC (J) (2004)).
8 Self-reactive substances and mixtures Not applicable - - - - The substance is classified into Division 5.1 (Oxidizing substances), PG II in UNRTDG (UN3247) though there are chemical groups (-O-O-) associated with explosive properties present in the molecules.
9 Pyrophoric liquids Not applicable - - - - Solid (room temperature)
10 Pyrophoric solids Not classified - - - - The substance does not fall into upper Division 4.2, PG I since it is classified into Division 5.1 (Oxidizing substances), PG II in UNRTDG (UN3247).
11 Self-heating substances and mixtures Not classified - - - - Information is available that sodium perborate tetrahydrate (10486-00-7) is not combustible (ICSC (J) (2004)).
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - Classification is not possible since no data are available though the substance contains metals (Na) and metalloids (B).
13 Oxidizing liquids Not applicable - - - - Solid (room temperature)
14 Oxidizing solids Category 2 Danger H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 2 since the anhydrite is classified into Division 5.1, PG II in UNRTDG (UN3247). Monohydrate is classified into Category 3 since it is classified into Division 5.1, PG III in UNRTDG (UN3377).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Due to lack of data for sodium perborate, data for sodium perborate tetrahydrate (CAS: 10486-00-7) or sodium perborate monohydrate (CAS: 10332-33-9) are used as the basis of classification. Anhydride equivalent LD50 values are 1120 mg/kg and 1200 mg/kg when sodium perborate tetrahydrate was administered to rats (PATTY (5th, 2001)) or 920 mg/kg, 1470 - 1720 mg/kg, 3000 mg/kg (male) and 2700 mg/kg (female) when sodium perborate monohydrate was administered to rats (PATTY (5th, 2001)). The substance was classified into Category 4 since many LD50 values are in this category. Anhydride equivalent LD50 values are reported to be 1120 mg/kg and 1200 mg/kg when sodium perborate tetrahydrate was administered to rats (PATTY (5th, 2001)) or 920 mg/kg, 1470 - 1720 mg/kg, 3000 mg/kg (male) and 2700 mg/kg (female) when sodium perborate monohydrate was administered to rats (PATTY (5th, 2001)). The substance was classified as Category 4 because many LD50 values are in this category.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LD50 value of sodium perborate monohydrate is >2000 mg/kg for rabbits (PATTY (5th, 2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Sodium perborate tetrahydrate is solid (GHS definition).
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data. Although a LC50 value of sodium perborate tetrahydrate is reported to be >0.074 mg/L for rats (EHC 204 (1998)), the exposure period was not clear.
2 Skin corrosion/irritation Not classified - - - - Based on a report that the substance was classified as not irritating in rat Draize tests where 500 mg of sodium perborate tetrahydrate or monohydrate was applied for 4-hour (PATTY (5th, 2001)) and a report that slight irritation was observed after application of sodium perborate tetrahydrate monohydrate to rabbits (PATTY (5th, 2001)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 or "Not classified" in GHS classification).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on a report of severely irritating after application of sodium perborate tetrahydrate powder to rabbits (PATTY (5th, 2001)) and a report of severely irritating after application of sodium perborate monohydrate powder to rabbits (PATTY (5th, 2001)), and classification as Xi; R41 in EU classification (EU-Annex I (access on Aug. 2009)), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a positive Ames test and a positive chromosomal aberration test (HSDB (2006)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is information that parental toxicity, increased embryo resorptions, and cardiovascular and skeletal malformations were observed at a limit dose level when sodium perborate tetrahydrate was administrated to rats (Birth Defects (3rd, 2000)). Since these malformations were observed at dose levels at which toxicity was manifested in parental animals and the substance is classified into Repr. Category 2; R61 and Repr. Category 3; R62 in EU classification (EU-AnnexⅠ (access on Aug. 2009)), the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data. There is information that the lowest concentration causing respiratory irritation in rat was 39 mg/m3 (PATTY (5th, 2001)), however, the details are not clear. The substance is classified into Xi; R37 in EU classification (EU-Annex I (access on Aug. 2009)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data. There is a report that in a 28-day test in rat given sodium perborate tetrahydrate at an oral dose of 1000 mg/kg/day (90-day equivalence: 311 mg/kg/day), histological changes in the stomach were observed that are probably attributable to the formation of hydrogen peroxide in the stomach (PATTY (5th, 2001)). In addition, there is a report that repeated oral use as a mouthwash or the ingestion of tablets and powders marketed as denture cleansers has caused injuries (HSDB (2006)). The information is not used as the basis of classification for specific target organ toxicity since they are considered to be effects by site of contact.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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