GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Cerium
CAS：7440-45-1
Result：
| ID: | 21A3705 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Category 1 |
|
Danger | H228: Flammable solids |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Classified into Category 1 since mishmetals (slabs, ingots, rods; mainly cerium) are classified into Division 4.1, PG II in UNRTDG (UN1333). |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | Classification is not possible since data on auto-ignition point are not available though the information is available that is "The substance spontaneously ignites in the air at 150 - 180 degC" (Sax (11th, 2004)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Category 2 |
|
Danger | H261: In contact with water releases flammable gas |
P231+P232: Handle under inert gas. Protect from moisture. P335+P334: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. P370+P378: In case of fire: Use ... for extinction. P402+P404: Store in a dry place. Store in a closed container. P223: Keep away from any possible contact with water, because of violent reaction and possible flash fire. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 2 since cerium (chips, sandy form) is classified into Division 4.3, PG II in UNRTDG (UN3078). However, the ingot is classified into Not classified. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Inorganic substance containing no oxygen and halogen atoms |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic substance |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
|
Danger | H370: Causes damage to organs (blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The anticoagulant effects of the substance were evaluated following a single dose to 18 patients. The toxic reactions of hemoglobinemia, and hemoglobinuria were reported (PATTY (5th, 2001)) and the substance was classified into Category 1 (blood system). In two rat tests, the effects on the cardiovascular (IRIS (Draft) (2008)) and liver (PATTY (5th, 2001)) were reported. As relevant information, the information was obtained from intravenous injection tests, therefore the results were not used as the basis for classification. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Although there are numerous case reports of workers developing interstitial lung disease or pneumoconiosis after occupational exposure to cerium compounds (including cerium oxide) and other rare earth elements, it can not be determined whether the effects were caused by cerium itself. In addition, there is a report that a dose and exposure period-dependent increase in abnormal spermatozoa was observed at dose levels of 200 mg/kg (90-day equivalence: 67 mg/kg) and higher in 30-day or 45-day oral tests in mice. However, classification was not possible due to lack of other sufficient data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 168h-LC50 = 0.032 mg/L for Crustacea (Hyalella azteca, Amphipods) (AQUIRE, 2010). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1since its acute toxicity is Category 1 and the behavior in water is unknown as it is inorganic compound. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |