GHS Classification Result

Chemical Name：Cobalt (II) nitrate hexahydrate
CAS：10026-22-9

Result：
ID: 21A3700
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification is not possible since no data are available though the substance contains chemical groups (R-NO3) associated with explosive properties present in the molecules. Oxygen balance is 0.00.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Classified into Not classified since the substance is not combustible but it enhances combustion of other substances (ICSC (J) 2001).
8 Self-reactive substances and mixtures Classification not possible - - - - Classification is not possible since no data are available though there are chemical groups (R-NO3) associated with explosive properties present in the molecules.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Classified into Not classified since the substance is not combustible but it enhances combustion of other substances (ICSC (J) 2001).
11 Self-heating substances and mixtures Not classified - - - - Classified into Not classified since the substance is not combustible but it enhances combustion of other substances (ICSC (J) 2001).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Judged to be stable against water since data are available that water solubility is 103 g/100 g H2O (25 degC) (Lide (88th, 2008)) though it contains metals (Co).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance is inorganic compound containing oxygen which is chemically bonded to atoms except carbon and hydrogen. Information is available that the substance is nitrate and "Enhances combustion of other substances." (ICSC (J) 2001).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LD50 value is 691 mg/kg for rats (RTECS (2009)). [For health hazards, refer also to cobalt chloride (II) (CAS: 7646-79-9) and cobalt sulfate (CAS: 10124-43-3)].
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		There is a report that bronchial asthma was reported in workers exposed to various forms of cobalt (CICADs 69 (2006)). Additionally, in Japan Society For Occupational Health (JSOH), cobalt is classified into Category 1 for respiratory tract sensitizer, but the following statement is found: "the substance and its compounds are included in the list of sensitizers, but all of them were recognized as sensitizers." (Recommendations for allowable concentrations (2008)). Therefore, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In Japan Society For Occupational Health (JSOH), cobalt is classified into Category 1 for skin sensitizer, but the following statement is found: "the substance and its compounds are included in the list of sensitizers, but all of them were recognized as sensitizers." (Recommendations for allowable concentrations (2008)). Therefore, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since cobalt and cobalt compounds are classified into 2B in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)), the substance was classified into Category 2. As relevant information, cobalt and cobalt compounds are classified into "Group 2B" in IARC (IARC 52 (1991)).
7 Reproductive toxicity Classification not possible - - - - No data available. As relevant information, some animal tests reported remarkable reproductive toxicity of cobalt compounds such as a male mouse 12-week drinking-water test with cobalt (II) chloride where the numbers of implantation sites and viable fetuses were reduced in unexposed females mated with exposed males. In rat, mouse and rabbit tests by oral administration of cobalt sulfate during organogenesis period, there was no adverse effect on fetuses at a dose at which general toxicity is manifested in maternal animals (CICADs 69 (2006)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available. As data for cobalt (II) chloride, there is a report that depression of spontaneous activity, muscle tone and respiration were observed at 4.25 mg/kg in a rat oral gavage test (ATSDR (2004)). As effects of cobalt chloride in human, retrosternal chest pain, tinnitus, nausea and vomiting, nerve deafness, thyroid hyperplasia with tracheal compression and myxedema were reported (HSDB (2004)). Additionally, there is a report that cobaltous chloride depress the production of erythrocytes and accidental intoxication in children may produce cyanosis, coma and death (HSDB (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, heart) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, heart) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		No data for the substance is available. However, there are many human case reports of effects on the lungs (degeneration, interstitial pneumonia, radiographic abnormality and pulmonary function impairment) caused by inhalation exposure to cobalt (Risk assessment report of cobalt and cobalt compounds (Ministry of Health, Labour and Welfare)). Several studies reported lethal cardiomyopathy in people who consumed large quantities of beer with cobalt sulfate (CICAD 69 (2006)). Many animal experiments showed that lung disorder, cardiac disorder, effects on the respiratory tract, effects on the thymus, or effects on larynx were caused by inhalation exposure to cobalt metal, cobalt chloride or cobalt sulfate (Risk assessment report of cobalt and cobalt compounds (Ministry of Health, Labour and Welfare)). Based on the above information, the substance was classified into Category 1 (respiratory system, heart).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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