GHS Classification Result

Chemical Name：Allyl isothiocyanate
CAS：57-06-7

Result：
ID: 21A3691
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 46 degC (closed-cup) (ICSC (1997)) is >=23 degC and <=60 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance, which contains stabilizer and is classified into Division 6.1, Subsidiary risk 3, PG III in UNRTDG (UN1545), is being distributed though there are chemical groups (C-C unsaturated bond) present in the molecule associated with self-reactive properties.
9 Pyrophoric liquids Not classified - - - - The substance does not fall into upper Division 4.2, PG I since it is classified into Division 6.1, Subsidiary risk 3, PG II in UNRTDG (UN1545).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). ERG in UN1545 falls under No.155, however the water-reactivity is not applicable to GHS classification.
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 339 mg/kg and 490 mg/kg for rats (NTP TR No. 234 (1982)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 88 mg/kg for rabbits (RTECS (2008), the original literature: TXAPA9 Toxicology and Applied Pharmacology. 42, 417, 1977), the substance was classified into Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on reports as human effects "irritates the mucous membranes and induced eczematous or vesicular skin reactions" and "the compound strongly irritates skin and mucous membranes" (IARC 73 (1999)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data. However, there is a description that the substance has a very pungent, irritating odor and the vapor can cause keratitis which interferes with vision (HSDB (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since the substance is on the Frosch contact allergen list (FROSCH, TEXTBOOK OF CONTACT DERMATITIS), the substance was classified into Category 1. As relevant information, a positive result in an open epicutaneous test using guinea pigs is reported in a document in List 2 (IUCLID (2000)).
5 Germ cell mutagenicity Not classified - - - - Based on negative results in dominant lethal tests by intraperitoneal injection to mice and oral administration to rats (in vivo heritable germ cell mutagenicity tests) (IARC 73 (1999)) and negative results in oral rat bone marrow chromosomal aberration test and intraperitoneal mouse bone marrow and peripheral blood micronucleus tests (in vivo somatic cell mutagenicity tests) (NTP DB (access on Sep. 2009)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test, a positive mouse lymphoma gene mutation test and a positive CHO cell chromosomal aberration test (NTP DB (access on Dep. 2009)).
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC 73 (1999)), the substance was classified as "Not classified". A 103-week oral test was conducted with rats and mice. Transitional-cell papillomas in the urinary bladder occurred in dosed male rats but not in control male rats, and fibrosarcomas in the subcutaneous tissue occurred in female rats, but no increased incidences of tumors were observed in mice. It was concluded that under the condition of this test, the substance was carcinogenic for male rats, equivocal for female rats and not carcinogenic for mice (NTP TR234 (1982)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a developmental toxicity test by oral administration to rats during organogenesis period, there was no effect on fetuses at a dose at which general toxicity is manifested in maternal animals (IARC 73 (1999)). However, in developmental toxicity tests by oral administration to mice, hamsters, and rabbits during organogenesis period, no evidence of treatment-related maternal toxicity and teratogenicity were observed in any species, but there was some increase in the incidence of dead fetuses and resorbed embryos in mice at the highest dose (IARC 73 (1999)). Although the substance corresponds to Category 1B based on toxicity at a dose at which general toxicity is not manifested in maternal animals, the substance was classified into Category 2 since the toxicity was observed in mice only.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity) Warning H371: May cause damage to organs (systemic toxicity) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In rats receiving orally 200 - 400 mg/kg, inactivity, watery eyes and ruffled fur were observed. After oral administration to mice, death occurred at dose levels of 400 mg/kg and higher. Toxic signs such as inactivity and ruffled fur were observed at dose levels of 100 mg/kg and higher, and dose related thicken and necrosis in mucosal surface of the stomach were noted (NTP TR (1982)). In another rat oral test (HSDB (2003)), rats were exhausted and died within 4-hour to 15 days after administration. The LD50 value was determined to be 339 mg/kg. As in the other tests, death and signs such as inactivity, ruffled fur and exhaustion, and gross lesions such as thicken and necrosis in mucosal surface of the stomach were observed at dose levels of 300 - 400 mg/kg or higher, within the guidance value range for Category 2. The substance was classified into Category 2 (systemic toxicity) since the affected organ cannot be identified.
9 Specific target organ toxicity - Repeated exposure Category 2 (systemic toxicity) Warning H373: May cause damage to organs through prolonged or repeated exposure (systemic toxicity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a rat 14-day oral test, all rats died at dose levels of 200 and 400 mg/kg (90-day equivalence: 31.1 and 62.2 mg/kg/day). Gross pathological lesions such as thickened mucosal surface of the stomach and adhesion of the stomach to the peritoneum and toxic signs such as inactivity and ruffled fur were observed at dose levels of 50 - 400 mg/kg (7.8 - 62.2 mg/kg/day) (NTP TR 234 (1982)). In a mouse 14-day oral test, one mouse died, and gross pathological lesions such as thickened mucosal surface of the stomach and thickened urinary bladder wall were observed at a dose level of 50 mg/kg/day (7.8 mg/kg/day) (NTP TR 234 (1982)). On the other hand, in rat and mouse 13-week oral tests, no exposure-related effects were observed in either species, and the NOEL was reported to be the highest dose tested (25 mg/kg/day) (NTP TR 234 (1982)). In summary, for rats, deaths were observed at dose levels of 200 mg/kg/day (90-day equivalence: 31.1 mg/kg/day) and higher. Changes in the stomach and toxic signs were observed at dose levels of 50 mg/kg/day (90-day equivalence: 7.8 mg/kg/day) and higher. For mice, one death and changes in the stomach and urinary bladder were observed at 50 mg/kg/day (90-day equivalence: 7.8 mg/kg/day). The substance was classified into Category 2 (systemic toxicity) since the affected organ cannot be identified.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 96h-LC50 = 0.077 mg/L for fish (Oryzias latipes) (AQUIRE, 2010).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information