GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Antimony trisulfide
CAS：1345-04-6
Result：
| ID: | 21A3689 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | The substance can be judged not to spontaneously ignite on contact with room temperature air from information such as "The substance burns on heating and its fine powder is oxidized gradually at room temperature." (Incompatible Hazard Handbook of Chemicals (Tokyo Fire Department, 1997)) or "The substance is incombustible." (IUCLID (2000)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Classified into Not classified since data on water solubility at around room temperature (ATSDR (1992), HSDB (2009)) are available. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Inorganic compounds containing no oxygen and halogen atoms |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on a LD50 value of >2000 mg/kg bw [converted from >1434 mgSb/kg bw by molecular-weight ratio] for rats (DFGOT vol. 23 (2007)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on a LD50 value of >2000 mg/kg bw for rats (DFGOT vol. 23 (2007)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - | - | Based on a LC50 value of >5 mg/L/4h (calculated from >3584 mgSb/m3 using molecular weight ratio) for rats (DFGOT vol. 23 (2007)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. As relevant information, there is a report that antimony fumes may cause skin irritation (Risk assessment report of antimony and antimony compounds (Ministry of Health, Labour and Welfare) (2009)). |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on results that slight corneal opacity was observed and was completely reversible within day 14 in a rabbit test following application of 100 mg (OECD TG405) (DFGOT vol. 23 (2007)), the substance was classified into Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. As relevant information, antimony and its inorganic compounds (inhalable fraction) are classified as "Germ cell mutagen group 3B" in MAK/BAT (DFGOT 23, 2007). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Based on the classification of "Group 3" in IARC (IARC 47 (1989)), the substance was classified as "Not classified". There is information that lung tumours occurred in females only in a rat test following repeated inhalation to antimony ore containing principally antimony trisulfide (IARC 47 (1989)). As relevant information, antimony and its inorganic compounds (inhalable fraction) are classified into "Carcinogenicity Category 2" in MAK/BAT (DFGOT 23, 2007). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Rats exposed to 3.1 mg/m3 by inhalation for six weeks developed electrocardiographic changes, notably with flattened T-waves. At autopsy, the heart was found to be dilated, with signs of degenerative changes. Focal haemorrhage and congestion in the lungs were considered to be secondary to heart failure (IARC 47 (1989)). A second report indicates that there had been six deaths suspected due to cardiac disorder in a group of 125 workers exposed for 8 months to 2 years, but there had been no cardiac death or unusual increase in incidence of cardiovascular diseases after use of antimony trisulfide was discontinued (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)). Based on these findings, the substance was classified into Category 1 (cardiovascular system). As relevant information, there is a report indicating an increase in the incidence of deaths from non-neoplastic respiratory disease after exposure of antimony (Risk assessment report of antimony and antimony compounds (Ministry of Health, Labour and Welfare) (2009)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |