GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：4-Nitro-o-phenylenediamine monohydrochloride
CAS：53209-19-1
Result：
| ID: | 21A3663 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance contains chemical groups (nitro group) associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification is not possible since no data are available though there are chemical groups (nitro group) associated with explosive properties present in the molecules. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains chlorine which is chemically bonded only to hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | No data are available for this substance. However, since a LD50 value of its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9) is 3720 mg/kg bw for rats (in oil-in-water emulsion, 4807 mg/kg bw in hydrochloride equivalence) (IARC vol. 16 (1978)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Although there are no available data for the substance, for its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9), there is a report that in a rabbit skin irritation test, the primary skin irritation score for a 2.5% concentration in aqueous gum tragacanth was 0, and for a 5.0% concentration in ethanol it was 0.38 and the substance was "nonirritating to rabbit skin" (HSDB (2008)). The substance was classified as "Not classified". |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | There are no available data for this substance. However, for its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9), there is a report that in a rabbit eye irritation test, mild conjunctival irritation that did not persist more than 24-hour was observed by application of concentrations of 2.5 percent in aqueous gum tragacanth and the Draize score was 3.0/110 for a 100 percent concentration. It was concluded that the substance was "nonirritating to rabbit eye" (HSDB (2008)). The substance was classified as "Not classified". |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Although there are no available data for this substance, for its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9), there is a report that "4/20 guinea pigs were sensitized" by applications of a 3% aqueous solution of this substance which also contained other additives (thickener and alcohol, etc.) in a guinea pig skin sensitization test (HSDB (2008)). The substance was classified into Category 1. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Although there are no available data from in vivo mutagenicity tests for the substance, since its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9) showed negative results in a rat dominant lethal test (intraperitoneal injection) (IARC 16 (1978)) and a rodent (rat, mouse, hamster) bone marrow chromosomal aberration tests (oral, intraperitoneal administration) (IARC vol. 16 (1978), NTP TR-180 (1979), NTP DB (access on Oct. 2009), HSDB (2008)), the substance was classified as "Not classified". From in vitro mutagenicity tests for the substance, there are reports of positive results in Ames test and Chinese hamster lung cell chromosomal aberration test (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law, Supplement (1997)). In addition, the substance is published as an existing chemical substance (Kihatsu 2-3, 1997), for which mutagenicity was established by Ministry of Health, Labour and Welfare. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | There are no available data for the substance. However, since its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9) is classified into "Group 3" in IARC (IARC suppl. 7 (1987)), the substance was classified as "Not classified". There is a report that 4-nitro-o-phenylenediamine was not carcinogenic in a feeding carcinogenicity test for 103 weeks with rats and for 102 weeks with mice (NTP TR-180 (1979)). |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There are no available data for the substance. However, for its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9), there is a report that in a mouse test by sc injection on days 6 - 15 of gestation, increased incidences of cleft palate and vascular malformation were observed at dose levels at which toxicity was manifested in parental animals (Teratogenic (12th, 2007), HSDB (2008)). Therefore, the substance was classified into Category 2. As relevant information, there is a report that no teratogenicity was observed by exposure to pregnant rats (dermal, feeding) or oral administration to pregnant rabbits (IARC vol. 16 (1978), NTP TR-180 (1979)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. For its free form, 4-nitro-o-Phenylenediamine (CAS No. 99-56-9), there is a report that haematological test and urine analysis showed no significant changes in a rabbit 13-week chronic exposure test (dermal) using a mixture with another substance (IARC vol. 16 (1978)). Additionally, there is a report that haematological test and urine analysis showed no significant changes in a dog chronic exposure test (in diet, unknown exposure period) using a mixture with another dye (IARC vol. 16 (1978)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |