GHS Classification Result

Chemical Name：Thiourea dioxide
CAS：1758-73-2

Result：
ID: 21A3659
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (room temperature)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (room temperature)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (room temperature)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Category 1 Danger H251: Self-heating; may catch fire P235+P410: Keep cool. Protect from sunlight.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P407: Maintain air gap between stacks/pallets.
P413: Store bulk masses greater than ... kg/... lbs at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials. 		Classified into Category 1 since the substance is classified into Division 4.2, PG II, III in UNRTDG (rev. 15, 2007) (UN3341). However, it may be classified into Category 2 or Not classified by composition and form and it is desirable to confirm by conducting the designated test (IMDG Code).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (room temperature)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance contains oxygen which is chemically bonded to atoms (S) except carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 1565 mg/kg (male) and 1496 mg/kg (female) (OECD TG401 (GLP)) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)) and 1120 mg/kg (SIDS(access on Oct. 2009)) for rats, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of >2000 mg/kg for rats (OECD TG402 (GLP)) (SIDS (access on Oct. 2009)), the substance was classified as "Not classified". It is unclear whether this substance was classified into Category 5 in GHS classification.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (room temperature)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LC50 value (4h) of 0.164 mg/L for rats (OECD TG403 (GLP)) (SIDS (access on Oct. 2009)), the substance was classified into Category 2. Since there was a report of "aerosol" (SIDS (access on Oct. 2009)), the test was considered to be conducted for dust.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Although there are no data available on 4-hour application tests, the substance was moderately irritating to the intact skin and the Draize score was 3.3 in a rabbit 24-hour patch test (SIDS (access on Oct. 2009)) and the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In a rabbit test, after 24-hour slight opacity of the cornea, slight iritis and moderate redness and slight to severe swelling of the conjunctivae were noted. Some of these effects recovered partially or completely in the course of the 7 day observation period. However, at 7 days slight to severe cornea opacity and vascularization of the cornea were observed in 4/6 rabbits, ulcus cornea in 2/6 rabbits, slight iritis in 3/6 rabbits and slight lesions of the conjunctivae in all rabbits. Based on a report of "severe" eye irritant (SIDS (access on Oct. 2009)), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although no sensitizing result was reported in a guinea pig Draize test (SIDS (access on Oct. 2009)), classification was not possible since the test method is not approved by OECD.
5 Germ cell mutagenicity Not classified - - - - From in vivo tests, a mouse bone marrow micronucleus test (OECD TG474 (GLP)) resulted in a positive result but there is a report that "it was recommended by external experts to repeat the test". Three additional mouse bone marrow micronucleus tests (OECD TG474 (GLP) was followed in 2 tests) resulted in negative results (SIDS (access on Oct. 2009)). Therefore, the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of positive results in two Ames tests (OECD TG471) (SIDS (access on Oct. 2009, "Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)), and a CHL/IU cell chromosomal aberration test (OECD TG473 (GLP)) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). Additionally, a negative result was reported for an in vitro HGPRT test using CHO cells (OECD TG476 (GLP)) (SIDS (access on Oct. 2009)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a combined repeat dose and reproductive/developmental toxicity test with rats (OECD TG422 (GLP)), decreases in estrus count, extension of the estrous cycle, numbers of corpora lutea and implantation, increased gestation days, all embryo absorption (3 dams), and decrease or decrease tendency in numbers of newborn, live newborn and the birth index were observed at doses at which parental effects such as decreased body weight gain were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). The substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 2 (kidney), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system)
H371: May cause damage to organs (kidney)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As effects on the respiratory system, in a rat 4-hour inhalation test (aerosol) (OECD TG403 (GLP)), clinical observations included difficulties in breathing, anemia and cyanosis as well as low locomotion at dose levels of 0.117 mg/L and higher. Necropsy revealed hemorrhages in the lungs at dose levels of 0.059 mg/L and higher, and histopathology revealed a corrosive action in the lung (multifocal fibrosis, inflammation, edema, congestion, loss of cilia etc.) at dose levels of 0.059 mg/L and higher. Trachea and nasal cavity were also affected (the details is not clear) (SIDS (access on Oct. 2009)). As effects on the kidney, in a rat oral test (OECD TG401 (GLP)), histopathology revealed grayish white in cortico-medullary junction area, basophilic renal tubule and interstitial fibrosis at dose levels of 1280 mg/kg and higher ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). Additionally, as narcotic effects, in a rat oral test, sedation, ataxia and reduced reflexes were observed at a dose level of 1120 mg/kg (SIDS (access on Oct. 2009). Based on the above information, the substance was classified into Category 1 (respiratory system), Category 2 (kidney) and Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		No increase in frequency of substance related symptoms were observed in 85 workers exposed to the substance (SIDS (access on Oct. 2009)). In a combined repeat dose and reproductive/developmental toxicity test with rats (OECD TG422 (GLP)), at a dose level of 100 mg/kg (90-day equivalence: 54.4 mg/kg), effects on the liver including centrilobular hypertrophy of hepatocytes, basophilic material in the bile duct, vacuolization of hepatocytes, changes in blood chemical examination (increases of albumin, A/G ratio, triglycerides and phospholipids, decreases of glucose) and effects on the kidney including necrosis of the tubules, basophilic tubules, changes in blood chemical examination (increases of BUN, creatinine and inorganic phosphorus, decreases of potassium) were noted ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). Based on the above information, the substance was classified into Category 2 (liver, kidney). As relevant information, although edema, pneumonia, emphysema and atelectasis in the lung, hyperplasia and metaplasia in the spleen, and desquamation of the follicle epithelium in the thyroid were noted in a rat 9-month inhalation test (IUCLID (2000)), the results were not used as the basis of classification since exposure period per day was unclear.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 72h-EC50 = 32 mg/L for algae (Scenedesmus subspicatus) (SIDS, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is rapidly degradable (Readily biodegradable, BOD degradation rate: 71 - 93%) (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991) and its bioaccumulative potential is estimated to be low (LogKow = -3.37 (PHYSPROP Database, 2011) though the acute toxicity is Category 3.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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