GHS Classification Result

Chemical Name:Octafluoropropane
CAS:76-19-7

Result:
ID: 21A3646
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Not classified - - - - Nonflammable gas (Merck (14th, 2006))
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not classified - - - - The substance is classified into Division 2.2 in UNRTDG (UN2424) and Subsidiary is not risk 5.1.
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temperature is 71.9 degC (Merck (14th, 2006)) exceeding 65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not classified - - - - Based on a LC0 value = 800,000 ppm/1h (400,000 ppm/4h) for rats (NICNAS (2001)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - No data available. As information in a document in List 3, although there is a report of "mild" irritating in a Draize test where 500 microL of the substance was applied to the skin of rabbits (RTECS (2006)), the detailed data such as irritation signs or scores are not clear.
3 Serious eye damage/eye irritation Classification not possible - - - - Although there are no reports of signs suggesting irritating in a 1-hour inhalation test with rats at 800,000 ppm, 10-day inhalation tests with rats and guinea pigs, or an inhalation mouse bone marrow micronucleus test, and the substance was concluded to be practically non-irritant from a result that there was no evidence of mucosal injury or retinal damage at cellular level after injection into the rabbit eyes (NICNAS (2001)), classification was not possible since the experimental procedures are not commonly used.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an inhalation mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (NICNAS File No. NA/46 (2001)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NICNAS File No. NA/46 (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Not classified - - - - Based on a report that all animals receiving inhalation of 800,000 ppm/1h (400000 ppm/4h) exhibited initial hyperactivity, followed by decreased activity but growth curves were considered normal and the substance was considered to show no acute toxicity at this dose level (NICNAS (2001)). Therefore, the substance corresponds to "Not classified" with inhalation exposure. Since the substance is a gas, it was classified as "Not classified" based on data from inhalation exposure only.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although increased incidences of interstitial pneumonitis caused by infection and necrosis in the liver were observed in a repeated inhalation test where rats and guinea pigs received approximately 10% in air for 10 days (NICNAS (2001)), classification was not possible due to lack of data since the test was conducted at high concentration exceeding the guidance value range and the experimental procedure did not meet current requirements.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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