Hazard class
|
Classification
|
Symbol
|
Signal word
|
Hazard statement
|
Precautionary statement
|
Rationale for the classification
|
1
|
Acute toxicity (Oral)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
1
|
Acute toxicity (Dermal)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
1
|
Acute toxicity (Inhalation: Gases)
|
Not classified
|
-
|
-
|
-
|
-
|
Based on a LC0 value = 800,000 ppm/1h (400,000 ppm/4h) for rats (NICNAS (2001)), the substance was classified as "Not classified".
|
1
|
Acute toxicity (Inhalation: Vapours)
|
Not applicable
|
-
|
-
|
-
|
-
|
Gas (GHS definition)
|
1
|
Acute toxicity (Inhalation: Dusts and mists)
|
Not applicable
|
-
|
-
|
-
|
-
|
Gas (GHS definition)
|
2
|
Skin corrosion/irritation
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available. As information in a document in List 3, although there is a report of "mild" irritating in a Draize test where 500 microL of the substance was applied to the skin of rabbits (RTECS (2006)), the detailed data such as irritation signs or scores are not clear.
|
3
|
Serious eye damage/eye irritation
|
Classification not possible
|
-
|
-
|
-
|
-
|
Although there are no reports of signs suggesting irritating in a 1-hour inhalation test with rats at 800,000 ppm, 10-day inhalation tests with rats and guinea pigs, or an inhalation mouse bone marrow micronucleus test, and the substance was concluded to be practically non-irritant from a result that there was no evidence of mucosal injury or retinal damage at cellular level after injection into the rabbit eyes (NICNAS (2001)), classification was not possible since the experimental procedures are not commonly used.
|
4
|
Respiratory sensitization
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
4
|
Skin sensitization
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
5
|
Germ cell mutagenicity
|
Not classified
|
-
|
-
|
-
|
-
|
Based on a negative result in an inhalation mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (NICNAS File No. NA/46 (2001)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NICNAS File No. NA/46 (2001)).
|
6
|
Carcinogenicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
7
|
Reproductive toxicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
8
|
Specific target organ toxicity - Single exposure
|
Not classified
|
-
|
-
|
-
|
-
|
Based on a report that all animals receiving inhalation of 800,000 ppm/1h (400000 ppm/4h) exhibited initial hyperactivity, followed by decreased activity but growth curves were considered normal and the substance was considered to show no acute toxicity at this dose level (NICNAS (2001)). Therefore, the substance corresponds to "Not classified" with inhalation exposure. Since the substance is a gas, it was classified as "Not classified" based on data from inhalation exposure only.
|
9
|
Specific target organ toxicity - Repeated exposure
|
Classification not possible
|
-
|
-
|
-
|
-
|
Although increased incidences of interstitial pneumonitis caused by infection and necrosis in the liver were observed in a repeated inhalation test where rats and guinea pigs received approximately 10% in air for 10 days (NICNAS (2001)), classification was not possible due to lack of data since the test was conducted at high concentration exceeding the guidance value range and the experimental procedure did not meet current requirements.
|
10
|
Aspiration hazard
|
Not applicable
|
-
|
-
|
-
|
-
|
Gas (GHS definition)
|