Chemical Name:1,2-Propanediamine
CAS:78-90-0
ID: | 21A3631 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2009 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 | Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 3 since flash point 33 degC (closed-cup) (ICSC (2006)) is >=23 degC and <=60 degC. | |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Auto-ignition point is 416 degC (ICSC (2006)) exceeding 70 degC. |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on a LD50 value of 2.23 g/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification). |
1 | Acute toxicity (Dermal) | Category 3 | Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a LD50 value of 0.50 mL/kg (0.436 g/kg) for rabbits (PATTY (5th, 2001)), the substance was classified into Category 3. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified | - | - | - | - | Based on no mortality in animals exposed at saturated vapour pressure concentration (42.3 mg/L, 25 degC) for 8-hour (PATTY (5th, 2001)) (4-hour equivalence: 84.6 mg/L), the substance was classified as "Not classified". |
2 | Skin corrosion/irritation | Category 1 | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
There are results of "corrosive" in a rabbit test by occluded dermal application of 500 microL for 24-hour (IUCLID (2000)) and "corrosive" in another rabbit test by dermal application of undiluted substance for 15 min (IUCLID (2000)). The substance is classified into C; R35 in EU classification (EU-Annex I (access on Sep. 2009)). Based on these data, the substance was classified into Category 1. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on a report that degree of irritating was grade 8 of 10 (the most severe injury; grade 10) in a rabbit test (PATTY (5th, 2001)), a result of "corrosive" in a rabbit test by application of 50 microL to the eye (IUCLID (2000)) and a result of "corrosive" in another rabbit test by application of 100 microL to the eye (IUCLID (2000)), the substance was classified into Category 1. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test (NTP DB (access on Sep. 2009), IUCLID (2000)) |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3 from its 72h-ErC50 = 68 mg/L for algae (Scenedesmus) (IUCLID, 2000). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Classified into Not classified from its 72h-NOEC = 9.4 mg/L for algae (Scenedesmus) (IUCLID, 2000) in the base data used for classification of acute toxicity though its acute toxicity is Category 3. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
|
Definitions / Abbreviations |
|
Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |