GHS Classification Result

Chemical Name：1,4-Diethylbenzene
CAS：105-05-5

Result：
ID: 21A3627
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 56 degC (closed-cup) (Hommel (1996)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2049).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 430 degC (Lide (88th, 2008)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on a LD50 value of >2000 mg/kg for rats ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access in Sep. 2009)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on a result of "moderate irritation and slight necrosis" by application of undiluted substance to rabbits (PATTY (5th, 2001)), the substance was classified into Category 2. As relevant information, there is a report of skin injury from contact as human health effects (HSDB (2003)).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Diethylbenzene tested by drop on a rabbit eye caused transient symptoms of irritation, but no injury was detected by fluorescein staining (HSDB (2003)). Additionally, it was reported that men exposed to 1000 ppm experienced eye irritation which rapidly diminished in intensity on continued exposure and a concentration of 2000 ppm caused immediately severe eye irritation, lacrimation (HSDB (2003)), and there is a report that diethylbenzene is an eye irritant (HSDB (2003)). Based on these information, the substance was classified into Category 2. [Data for diethylbenzene was used as the basis of classification on the assumption that there are only minor differences between isomers.]
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Sep. 2009)) and a negative Chinese hamster CHL cell chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Sep. 2009)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a combined repeat dose and reproductive/developmental toxicity test with rats (OECD TG422), there were no effects on mating, fertility and oestrus cycle and all gestation animals delivered pups normally ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Sep. 2009)). Although there was no adverse effect on sexual function and fertility of parental animals, classification was not possible due to lack of sufficient data for fetal development including teratogenicity.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In a rat acute oral toxicity test (OECD TG401 (GLP)), decrease of spontaneous motor activity and lacrimation were observed at a dose level of 2000 mg/kg but no changes in body weight or treatment-related gross pathological changes were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Sep. 2009)). Based on this result, the substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of data with other exposure routes (inhalation, dermal).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a combined repeat dose and reproductive/developmental toxicity test with rats (OECD TG422 (GLP)), increases in BUN and GPT were observed at 150 mg/kg/day (90-day equivalence: 75 mg/kg/day) and 750 mg/kg/day (90-day equivalence: 375 mg/kg/day), and increases in total protein, albumin, creatinine and total bilirubin were observed at 750 mg/kg/day. As the gross findings, increases in incidence of brown colored livers or enlargement of the livers were observed in male rats receiving 750 mg/kg/day, and swelling of centrilobular hepatocytes was observed histopathologically. Although morphological changes in the liver were observed at a high dose level (90-day equivalence: 375 mg/kg/day) which exceeds the guidance value range, some biochemical changes such as increased enzyme activity were observed at a middle dose level (90-day equivalence: 75 mg/kg/day) which is within the guidance value range. Therefore, classification was not possible due to lack of data for evidence of effects at the upper limit (100 mg/kg/day) of the guidance value range. The above information come from "Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Sep. 2009). For health hazards, refer also to the information of 1,2-diethylbenzene (CAS 135-01-3).
10 Aspiration hazard Classification not possible - - - - Although the substance is a hydrocarbon, classification was not possible since the kinematic viscosity at 40 degC was unknown.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 96h-LC50 = 1.8 mg/L for fish (Oryzias latipes) (SIDS, 1994).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1988).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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