NITE - Chemical Management Field

GHS Classification Result

Chemical Name：1,3-Diethylbenzene
CAS：141-93-5

Result：


ID:	21A3626
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 3 since flash point 56 degC (closed-up) (Hommel (1996)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2049).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 450 degC (Chapman (Ver. 17.1, 2009)) exceeding 70 degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	Classification not possible due to lack of data. As relevant information, all 10 animals died at 5000 mg/kg (PATTY (5th, 2001)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available. For health hazards, refer also to 1,4-diethylbenzene (CAS 105-05-5).
3	Serious eye damage/eye irritation	Category 2		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Diethylbenzene tested by drop on a rabbit eye caused transient symptoms of irritation, but no injury was detected by fluorescein staining (HSDB (2003)). Additionally, it was reported that men exposed to 1000 ppm experienced eye irritation which rapidly diminished in intensity on continued exposure and a concentration of 2000 ppm caused immediately severe eye irritation, lacrimation (HSDB (2003)), and there is a report that diethylbenzene is an eye irritant (HSDB (2003)). Based on these information, the substance was classified into Category 2. [Data for diethylbenzene was used as the basis of classification on the assumption that there are only minor differences between isomers.]
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available. For health hazards, refer also to the information of 1,4-diethylbenzene (CAS 105-05-5).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available. Refer also to the information of 1,4-diethylbenzene (CAS 105-05-5).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Although there is a report that slight hemorrhage and dystrophic change were observed in the liver, gastric mucosa, duodenum, spleen and kidney following oral application of isomer mixture to rats (PATTY (5th, 2001)), classification was not possible due to lack of data for the substance itself rather than isomer mixture. For health hazards, refer also to the information of 1,4-diethylbenzene (CAS 105-05-5).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No data available. For health hazards, refer also to the information of 1,2-diethylbenzene (CAS 135-01-3) and 1,4-diethylbenzene (CAS 105-05-5).
10	Aspiration hazard	Classification not possible	-	-	-	-	Although the substance is a hydrocarbon, classification was not possible since the kinematic viscosity at 40 degC was unknown.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 2 from its 96h-LC50 = 4.15 mg/L for fish (Fathead minnow) (AQUIRE, 2010; HSDB, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable from BOD degradation rate = 0% at 4 weeks (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1988).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）