GHS Classification Result

Chemical Name:Cyclopentanol
CAS:96-41-3

Result:
ID: 21A3611
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into Category 3 since flash point 51 degC (closed-cup) (UNRTDG (15th, 2007)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 375 degC (GESTIS (access on Aug. 2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
From a report that mortality was 5/5 at 1.25 mL/kg (1188 mg/kg) and 5/6 at 0.625 mL/kg (594 mg/kg) in a rat test (HSDB (2003)), the substance corresponds to the category with higher hazard than Category 4. However, a dermal LD50 value is 134 mg/kg. Since the oral absorption was estimated to be similar or greater than the dermal absorption, the substance was classified into Category 3 exceptionally. Also, it could be classified into Category 2.
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on a LD50 value of 0.141 mL/kg (134 mg/kg) for rabbits (HSDB (2003)), the substance was classified into Category 2.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, the test substance was administered to rats for 136 minutes (100% mortality) or 68 minutes (no mortality) at saturated vapour pressure concentration and LT50 was determined to be 96 minutes (HSDB (2003)).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on a report that no irritation was noted on 4 rabbits and moderate capillary injection was noted on one rabbit in a primary dermal irritation test where either undiluted substance or diluted substance (10, 1, 0.1, 0.01%) was applied in 0.01 mL amounts to the skin of 5 rabbits (HSDB (2003)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on a result in an eye irritation test using 3 rabbits (OECD TG405 (GLP)) where irritation index MMAS (correspond to AOI) was 21.7, corneal opacities and conjunctivae redness were observed in 1/3 rabbit until day 7 after application and the effects were completely reversible on day 14 (ECETOC TR48 (1998)), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a rat oral test at 0.625 mL/kg (594 mg/kg) and 1.25 mL/kg (1188 mg/kg) which are within the guidance value range for Category 2, toxic signs such as sluggish, unsteady gait and convulsions were observed and gross pathology revealed mottled red and tan livers and pale kidneys. Almost all rats died at 0.625 - 2.5 mL/kg (594 - 2376 mg/kg). In a rabbit dermal test, at 0.2 mL/kg (190 mg/kg) and higher doses which are within the guidance value range for Category 1, lacrimation and convulsions were observed and gross pathology revealed mottled red and light tan livers and pale kidneys. The LD50 was determined to be 0.141 mL/kg (134 mg/kg). The animals died at dose levels within the guidance value ranges for both oral and dermal routes. This information are reported in a document in List 2. Neurologic symptoms such as convulsion were observed with both the oral and dermal routes. The substance was classified into Category 2 (central nervous system) (HSDB (2003)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Classified into Not classified from its 24h-EC50 = 129.5 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble from water solubility = 130,000 mg/L (PHYSPROP Database, 2010).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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