GHS Classification Result

Chemical Name:2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene (alpha-Pinene)
CAS:80-56-8

Result:
ID: 21A3601
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into Category 3 since flash point 33 degC (closed-cup) (HSDB (2009)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2368).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 255 degC (Chapman (Ver. 17.1, 2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on a LD50 value of 3700 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on a LD50 value of >5000 mg/kg for rabbits (IUCLID (2000)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Although there is information of a LCLo value of 625 microg/m3 for rats (PATTY (5th, 2001)), classification was not possible since determination of category was impossible. Since the toxicity value (LCLo: 625 microg/m3) is lower than 90% of saturated vapour pressure concentration (34.8 mg/L), the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas was adopted.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on results of "moderately irritating" in rabbit tests by dermal application for 4 or 24-hour (Pesticide safety information (Japan Crop Protection Association) vol. 17 (1994), IUCLID (2000)) and a report that primary dermal irritation index was 4.7 in a 4-hour dermal application test (Pesticide safety information (Japan Crop Protection Association) vol. 17 (1994)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In an irritation test using 6 rabbits where 0.1 mL undiluted substance was applied to the eye, 1 animal showed iritis and 6 animals showed minimal to moderate irritating on the conjunctivae at 1-hour after application but these effects were reversible within 48-hour and no corneal effects were observed. Based on the rating of minimally irritating (Pesticide safety information (Japan Crop Protection Association) vol. 17 (1994)), the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Since the substance is on the Frosch contact allergen list (FROSCH, TEXTBOOK OF CONTACT DERMATITIS), the substance was classified into Category 1. As relevant information, a positive result in an open epicutaneous test using guinea pigs is reported in a document in List 2 (IUCLID (2000)).
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a 13-week inhalation mouse peripheral blood micronucleus test (in vivo somatic cell mutagenicity tests) (NTP DB (access on Sep. 2009)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on Sep. 2009)).
6 Carcinogenicity Not classified - - - - Based on the classification of "A4" in ACGIH (ACGIH-TLV (2001)), the substance was classified as "Not classified".
7 Reproductive toxicity Classification not possible - - - - In animal tests where pregnant animals were administered orally from days 6 to 15 of gestation for mice, from days 9 to 14 of gestation for rats and from days 6 to 10 of gestation for hamster, there were no effects on parental animals except that maternal weight loss and placental and fetal weight loss were reported in rats at the highest dose level. No significant differences between dose group and the control group were reported for any parameter of fetal development or teratogenic effects were not observed (HSDB (2009)). However, classification was not possible since there are no data for effects on sexual function and fertility by exposure before mating.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a report that in a mouse inhalation test, (+) enantiomer showed persistent sensory irritation effect on the upper respiratory tract during exposures in the range of 100 to 3691 ppm and airflow limitation at concentrations of 200 ppm and higher. The (-) enantiomer showed lower a effect, producing only a short-lasting sensory irritation effect at concentrations above 2900 ppm and airflow limitation at 2000 ppm and higher (HSDB (2009)). Although these results correspond to Category 1 based on guidance value range, the substance was classified into Category 2 (respiratory system) because of information in List 2. As relevant information, there is a report that five subjects experienced irritation to the eyes, nose and throat in a exposure test employing eight volunteers and the incidence was statistically significant (ACGIH (2003)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
There is a report that prolonged exposure has resulted in palpitation, dizziness, nervous disturbances, chest pain, bronchitis, and nephritis in human experience (PATTY (5th, 2001)). There are many case reports that prolonged exposure of monoterpenes including alpha-pinene caused respiratory disturbances and a report of CNS depression (ACGIH (2003)). Based on this information, the substance was classified into Category 1 (respiratory system, nervous system).
10 Aspiration hazard Classification not possible - - - - No data available. As relevant information, the substance is a hydrocarbon with kinematic viscosity of 1.525 mm2/s (25 degC) and there is a report of "aspiration into the lung may result in chemical pneumonitis" (ACGIH (2003)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 96h-LC50 = 0.18 mg/L for fish (Fathead minnow) (HSDB, 2009).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and it is suspected that its bioconcentration potential is high from LogPow = 4.83 (PHYSPROP Database, 2010).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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