NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Ethyl propionate
CAS：105-37-3

Result：


ID:	21A3583
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2		Danger	H225: Highly flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 2 since flash point 12 degC (closed-cup) (Merck (14th, 2006)) is <23 degC and initial boiling point 99 degC (Merck (14th, 2006)) is >35 degC. The substance is classified into Class 3, PG II in UNRTDG (UN1195).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 475 degC (Hommel (1996)) exceeding 70 degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on LD50 values of 8732 mg/kg, 9550 mg/kg (male) and 8670 mg/kg (female) for rats (HSDB (2002)), the substance was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on a mortality of 1/10 at 14000 mg/kg in a rabbit test (HSDB (2002)), the substance was classified as "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Since all rats died during 45-minute exposures at saturated vapour pressure concentration (47105 ppm; 196.8 mg/L) (4-hour equivalence: 85.2 mg/L/4h) (HSDB (2002)), the substance corresponds to "Not classified". Classification was not possible since determination of category was impossible.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on a report that no indications of irritation were observed in any animal during 7-day post-treatment observation in a rabbit test by occluded dermal application for 4-hour (HSDB (2002)), the substance was classified as "Not classified". As relevant information, it is reported that one rabbit died at 7 days post-treatment but the mortality could not be related to treatment.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In an eye irritation test using 6 rabbits, iritis and moderate conjunctival irritation with marked discharge were apparent in all treated eyes by 4-hour post-instillation, and 2/6 eyes appeared normal within 24-hour but the remaining 4/6 eyes displayed slight, persistent conjunctival redness. All eyes were clear of any sign of irritation by 48-hour post-instillation (HSDB (2002)). Since the mean scores are judged to be 0 for all reactions at 24, 48 and 72-hour after installation with the exception that the mean score for conjunctival redness was estimated to be 1 or less at 24-hour after installation, the substance was classified as "Not classified".
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on Aug. 2009)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	In rats, oral treatment was associated with sluggishness, prostration, and mortality at approximately 15 minutes to 3-hour post-dosing at dose levels of 11.3 mg/kg (10080 mg/kg) and higher but no toxic effects were observed at dose levels of 8.0 mL/kg (7136 mg/kg) and lower (HSDB (2002)). By percutaneous application of 16 mL/kg bw (14000 mg/kg) to rabbits, one female was emaciated at death, however, no signs of systemic toxicity were observed in the other rabbits (HSDB (2002)). When rats were exposed to saturated vapour (estimated concentration 197 mg/L) for 11.2, 22.5 and 45 minutes, clinical signs of toxicity included labored breathing, hypoactivity, slowed breathing, slow or negative surface righting reflex, and negative toe and tail pinch reflex. 9 of 10 rats died during 45-minute exposure. The LT50 was reported to be 35 - 32 minutes. (HSDB (2002)). Based on the data, the substance corresponds to "Not classified" with oral exposure since no toxicity was observed at dose level of 7136 mg/kg and lower. However, with dermal and inhalation routes, adverse effects including death were observed at a dose level exceeding the guidance value range with no data at a dose level near the cut-off value. Overall, classification was not possible.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Although there is information that no adverse symptoms were noted in workers exposed to 375 to 1500 ppm for several months (HSDB (2002)), classification was not possible since the details are unclear and the original literature can not be confirmed.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3 from its 48h-LC50 = 44 mg/L for Crustacea (Daphnia cucullata) (AQUIRE, 2010).
11	Hazardous to the aquatic environment （Long-term）	Category 3	-	-	H412: Harmful to aquatic life with long lasting effects	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3 since its acute toxicity is Category 3 and there are no reliable data on rapid degradation.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）