GHS Classification Result

Chemical Name：Chlorotrimethylsilane
CAS：75-77-4

Result：
ID: 21A3558
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 2 (>35 degC) since flash point is -28 degC (Closed-cup) (Hommel (1996)) and -18 degC (Chapman (Ver. 17.1, 2009)), and initial boiling point is 57 degC (Chapman (Ver. 17.1, 2009)). The substance is classified into Class 3, PG II in UNRTDG (UN1298).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 395 degC (ICSC (J) (2002)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Classified into Not classified since the substance contains metalloids (Si) and explosively decomposes on contact with water (IUCLID (2000)), but gas formed is not combustible hydrogen chloride (ICSC (J) (2002)).
13 Oxidizing liquids Not classified - - - - Classified into Not classified since information is available that the substance contains chlorine (but not oxygen or fluorine) bonded to metalloids and is "Not oxidizing agent" (IUCLID (2000)).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available. Information is available that the substance attacks many metals in presence of water (ICSC (J) (2002)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 100 - 300 mg/kg bw for rats (vehicle: olive oil) (IUCLID (2000)), the substance was classified into Category 3. As relevant information, there are LD50 values of 4868 mg/kg and 5700 mg/kg when diluted in Silicone L-45 oil (HSDB (2007)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 1500 - 2000 mg/kg bw for rats (IUCLID (2000)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 value of 1498 ppm/4h for rats (OECD TG403) (IUCLID (2000)), the substance was classified into Category 3. Since the LC50 value was lower than 90% of saturated vapour pressure concentration (307,895 ppm), the substance was determined as "vapour with almost no included mists", and classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a report of "Necrosis, accompanied by severe erythema, moderate edema, and desquamation was observed within 1-hour after application of 0.5 mL to the skin of rabbits for 4-hour. The effects persisted through 1-week observation period. Although the skin primary irritation index was 2.2/8.0 (HSDB (2007)), the substance was classified into Category 1 based on a report of "highly corrosive" in another rabbit test (IUCLID (2000)) and a report of "corrosive to the skin" (HSDB (2007)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Although there is a report of "corneal injury, iritis, and moderate to severe conjunctivitis with necrosis observed after application of 0.005 mL undiluted substance to the eye of rabbits with a maximum mean Draize score of 31.5/110" (HSDB (2007)), the substance was classified into Category 1 based on a report of "highly corrosive" in another rabbit test (IUCLID (2000)) and another report of "corrosive to the eye" (HSDB (2007)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a rat bone marrow chromosome aberration test (in vivo somatic cell mutagenicity tests) (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there are reports of negative in almost all Ames tests (NTP DB (access on Aug. 2009)), and equivocal in mouse lymphoma chromosomal aberration test ((IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity, respiratory system) Warning H371: May cause damage to organs (systemic toxicity, respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		After oral administration of 172 - 688 mg/kg to rats, sluggishness, dyspnea and prostration were observed, and death followed within 30 minutes to two days. At necropsy, red to black stomachs and intestines, blanched livers, black stomach contents and red fluid in thoracic cavities were seen (HSDB (2007)). After exposing rats to vapour concentration of 10.414 - 16.840 mg/L, the animals of the highest concentration group died, and survivors showed nasal crust, rough coat and decreased body weight gain. At necropsy, major findings included corneal opacity and diffuse or focal dark coloured areas of the lungs (HSDB (2007)). After dermal application of 860 - 3440 mg/kg to rabbits, systemic effects including sluggishness, unsteady gait, and diarrhea were observed and death occurred at 30 minutes to eight days. At necropsy, livers with pink to dark red areas were seen (HSDB (2007)). The toxic signs and pathological findings were observed at dose levels within the guidance value range for Category 2 by oral, dermal and inhalation route, but the affected organ could not be identified. Therefore, the substance was classified into Category 2 (systemic toxicity). In addition, as human effects, there are reports that inhalation of vapour irritates mucous membranes and cause severe irritation of throat (HSDB (2007)) and that the substance and its vapour are corrosive to the respiratory tract and may cause lung edema. Additionally, symptoms by inhalation include burning sensation, cough, sore throat, labored breathing, shortness of breath (HSDB (2007)). Based on this information reported in a document in List 2, the substance was classified into Category 2 (respiratory system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is a result that no toxic effects were observed by inhalation exposure of 34 ppm (0.151 mg/L) to rats for 2 weeks (IUCLID (2000)), the tested dose level is under the upper limit of the guidance value range for Category 1 (50 ppm), therefore, classification was not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information