GHS Classification Result

Chemical Name：1-Pentanol
CAS：71-41-0

Result：
ID: 21A3545
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 33 degC (closed-cup) (Ullmanns (E) (2003)). The substance is classified into Class 3, PG III in UNRTDG (UN1105).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 300 degC (Lide (88th, 2008)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50 values of 2690 mg/kg and 3030 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of 2000 mg/kg, 4500 mg/kg (PATTY (5th, 2001)), and >3200 mg/kg (PATTY (5th, 2001)) for rabbits, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, no mortality was observed in rats exposed to saturated vapours of the substance (estimated concentration: 6.2 mg/L/8h (8.8 mg/L/4h)) at 22 degC (IUCLID (2000)).
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on a report that 2/10 rats died during the exposure of the aerosol at 14 mg/L/6h (21mg/L/4h) (PATTY (5th, 2001), a LC50 value was >14 mg/L/6h (21mg/L/4h) and the substance was classified as "Not classified".
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on a report that severe irritation was observed after a 24-hour closed application to rabbits (PATTY (5th, 2001)) and EU classification as Xi; R37/38 (EU-Annex I (access on May 2009)), the substance was classified into Category 2. As relevant information, there are reports "irritating for rabbits" (IUCLID (2000)) and "not irritating after 4-hour closed application to rabbits" (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on a report that application to rabbits caused severe irritation such as redness and swelling of the conjunctivae, iritis and corneal injury (PATTY (5th, 2001)), a report of reversible severe irritating in a rabbit Draize test (IUCLID (2000)) and severe corneal injury in rabbits with a degree of irritation of 8 of 10 (IUCLID (2000)), the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test (NTP DB (access on Aug. 2009), a negative human lymphocytes chromosome aberration test (IUCLID (2000)), and a positive V-79 cell chromosome aberration (including aneugenic) test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Although there is a report that there was no evidence of developmental toxicity in a rat test by repeated inhalation of saturated vapours on days 1 to 19 of gestation (PATTY (5th, 2001)), classification was not possible due to lack of data for sexual function and fertility of parental animals.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since neurotoxic effects include delirium, deafness, diplopia, CNS depression, preconvulsive movement were reported as human health effects (HSDB (2006)) and the information are reported in a document in List 2, the substance was classified into Category 2 (central nervous system). In addition, based on a report that the vapour may be irritating to upper respiratory tract (HSDB (2006)) and classification into Xi; R37/38 in EU classification (EU-Annex I (access on May 2009)), the substance was classified into Category 3 (respiratory tract irritation). Additionally, there is a report that appreciable lung edema was observed in the mice inhaling the aerosol at a dose exceeding the upper limit of the guidance value range for Category 2 (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a rat repeat oral administration test at dose levels of up to 1000 mg/kg for 13 weeks, there were no treatment related effects on food and water consumption, hematologic and serum chemistry values, urinalysis, renal function, organ weights, or histopathology (PATTY (5th, 2001)). The substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of data with other exposure routes.
10 Aspiration hazard Classification not possible - - - - Since the kinematic viscosity is estimated to be 14 mm2/s or less at 40 degC, extrapulated from 4.1 mm2/s (20 degC), (Ullmanns (E) (2003)) and the substance is n-primary alcohols with a composition of at least 3 carbon atoms but not more than 13, the substance corresponds to Category 2 in GHS classification. However, classification was not possible according to guidance of JIS Classification in which category 2 is not set. As relevant information, there is information that aspiration of 0.2 mL caused deaths in 10 out of 10 rats (PATTY (5th, 2001)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 48h-EC50 = 53 mg/L for Crustacea (Ceriodaohnia dubia) (AQUIRE, 2010)
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is rapidly degradable (BOD: 87, 95, 94%, TOC: 100, 98, 99, GC: 100, 100, 100% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2008)) and its bioaccumulation potential is estimated to be low (log Kow = 1.51 (PHYSPROP Database, 2010)) though its acute toxicity is Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information