GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-Amino-4-chlorophenol
CAS：95-85-2
Result：
| ID: | 21A3535 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification is not possible since no data are available though there are chemical groups (haloanilines) present in the molecule associated with self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Auto-ignition point is 500 degC (ICSC (2006)) exceeding 70 degC. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains chlorine and oxygen which are chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on a LD50 value of 690 mg/kg bw for rats (Cosmetic Ingredient Review Expert Panel (2004), Final report of the safety assessment., International Journal of Toxicology, 23 (Suppl. 2), 1-22 (2004)), the substance was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification not possible due to lack of data. A skin sensitization test was conducted on guinea pigs (15 animals/group) using Freund's Complete Adjuvant Test. After induction, this substance was applied at concentrations of 0.1, 0.5 and 1% for challenge exposure, and observations were made at 2 - 3 weeks, 4 weeks and 6 weeks later. A positive reaction was observed in 1, 3 and 5 animals at 2 - 3 weeks; 2, 8 and 13 animals at 4 weeks; and 2, 7 and 14 animals at 6 weeks at the concentration of 0.1, 0.5 and 1%, respectively. One animal died at 6 weeks (Cosmetic Ingredient Review Expert Panel (2004) Final report of the safety assessment, International Journal of Toxicology, 23 (Suppl. 2), 1-22.). This data may not be used for classification since the test method is not approved by OECD. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a weak positive Ames test (NTP DB (access on Aug. 2009)). The substance is an existing chemical substance for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law. |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
From Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2008) (104-week oral), there is a result that "Incidences of squamous cell carcinoma and papillomas in the forestomach, and transitional cell carcinoma in the urinary bladder were increased in male F344/DuCrlj (Fischer) rats by administration of 2-amino-4-chlorophenol, which was clear evidence of carcinogenic activity in male rats. There was evidence of carcinogenic activity in female rats, based on an increased incidence of squamous cell papillomas in the forestomach in females. In B6D2F1/Crlj mice, there was evidence of carcinogenic activity in males, based on an increased incidences of squamous cell papillomas in the forestomach. There was no clear increase in incidence of any tumor in female mice." The substance was classified into Category 2. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In a combined repeat dose and reproductive/developmental toxicity test in rat (OECD TG422 (GLP)) by Ministry of Economy, Trade and Industry (2008), there were no substance related effects on the parental animals or their offspring. However, since data for developmental toxicity are insufficient, classification was not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. As relevant information, there are reports that "Short term exposure can interfere with the ability of the blood to carry oxygen" (SITTIG (5th, 2008)) and "irritate the skin, eyes and mucous membranes" (combined repeated dose and reproductive/developmental toxicity test in rat by Ministry of Economy, Trade and Industry (2008)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In a combined repeat dose and reproductive/developmental toxicity test in rats (OECD TG422 (GLP)) by Ministry of Economy, Trade and Industry (2008), anemia was observed in both sexes of the 50 mg/kg (90-day equivalent: 23 mg/kg) and higher dose groups without histopathology abnormalities. Treatment at 250 mg/kg (90-day equivalent: 117 mg/kg) resulted in the death of three females. Hematological examination indicated anemia in both sexes from all test groups. Additionally, enlargement, increased extramedullary hematopoiesis and increased hemosiderin deposit in the spleen and extramedullary hematopoiesis in the bone marrow were observed. For these findings, there is a report "changes suggesting methemoglobinemia were observed". Therefore, the substance was classified into Category 2 (blood system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |