GHS Classification Result

Chemical Name：3-Hydroxy-2-naphthoic acid
CAS：92-70-6

Result：
ID: 21A3528
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is >400 degC (IUCLID (2000)) exceeding 70 degC.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen in the molecule which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 823 mg/kg bw and 1040 mg/kg bw for rats (SIDS (2004)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a LD50 value of approximately 1000 - 2000 mg/kg bw for guinea pigs (SIDS (2000)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on results that very slight erythema and oedema were observed but completely reversible at 48-hour and the skin primary irritation index was 0.3 in a rabbit test (OECD TG404 (GLP)) (SIDS (2004)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In a rabbit test (OECD TG405 (GLP)), at 1-hour after application, swelling and conjunctival injection as well as secretion were observed in all 3 animals. At 24, 48 and 72-hour, conjunctivitis and diffuse corneal opacities were found and 1 animal showed iritis. At 7 days after the application, corneal erosion and vascularization were observed in all animals. The effects were not reversible until test end (14 days after treatment) (SIDS (2004)). Although the reversibility within 24 days was not clear, mean Draize scores at 24 to 72-hour were 1.1 for corneal opacity, 1.9 for conjunctivitis and 1.3 for conjunctival swelling (SIDS (2004)). Additionally, the undiluted compound produced transient mild irritation of a rabbit eye (SIDS (2004)). Based on these information, the substance was classified into Category 2A, not corresponding to a corrosive substance.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a result of a positive ratio 66.7% (6/9) in a modified guinea pig maximization test (SIDS (2004)), the substance was classified into Category 1. Although there are results of "not sensitizing" in another guinea pig maximization test and a human patch test (SIDS (2004)), a small number of animals or subjects were used in both tests, especially, in the human patch test. Therefore, it was reported that no final assessment could be drawn due to the small number of subjects (8 subjects) tested (SIDS (2004)).
5 Germ cell mutagenicity Not classified - - - - Based on reports of negative results from an in vivo somatic cell mutagenicity tests, a mouse bone marrow micronucleus test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2005)) and a Chinese hamster bone marrow chromosomal aberration test (SIDS (2004)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (SIDS (2004)), and a positive only without metabolic activation in Chinese hamster lung cell chromosomal aberration test (SIDS (2004)). The substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a one-generation reproduction toxicity test by oral administration to rats, no abnormality was found in mating, fertility, delivery and nursing condition. Furthermore, there was no effect on birth index, general condition and viability of the offspring. However, at the high dose where transient salivation and reduced bodyweight gain were observed in parental animals, there was an increase in the incidence of offspring with external malformations, such as kinked tail, brachyury or microphthalmus. Additionally, visceral malformations such as undescended testes, hypoplasia of the spleen or diaphragmatic hernia were observed. Although all malformations were found only in offspring of a few limited litters, it was concluded that teratogenicity could not be ruled out from the results of this test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2005)). Therefore the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity) Warning H371: May cause damage to organs (systemic toxicity) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a rat acute oral toxicity test (OECD TG401) (SIDS (2004)), reduced activity, prostrate and lateral positioning were observed at 315 - 800 mg/kg. Additionally, accelerated breathing and closure of eyes were observed at 1000 - 1250 mg/kg. Diarrhea was seen in all groups. At necropsy, dark coloration and light-coloured spots of the liver and hyperemia in the gastro-intestinal tracts were observed in animals that had died. Animals surviving at the end of the 14-day observation period were free of pathological changes. Since the LD50 value (823 - 1040 mg/kg) is within the guidance value range for Category 2 and the affected organ cannot be identified from above clinical signs and pathological findings, the substance was classified into Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a rat 28-day repeat oral dose test (OECD TG407), changes in serum phosphate and serum bilirubin levels and increased liver weight were observed in the high dose group of 300 mg/kg/day (90-day equivalent: 93.3 mg/kg/day). Microscopically, necroses of the adrenal cortex were found in one female of the mid- and high-dose group (SIDS (2004)), however, there are insufficient data to consider these changes as exposure related effects. Additionally, from the report that kidney disturbances, increases in blood urea/nitrogen levels, and microscopically kidney changes including necroses were observed by 10-day inhalation exposure to rat at 100 mg/m3 (SIDS (2004)), the effect on the kidney is suggested. However, there were no effects on the kidney in the 28-day oral test and these information are reported in a citation document requiring confirmation of the original literature for classification. Therefore, classification was not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 48h-EC50 = 33 mg/L for Crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (Non-biodegradable, decomposition by BOD degradation rate: 19.9% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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