GHS Classification Result

Chemical Name:p-Benzoquinone dioxime
CAS:105-11-3

Result:
ID: 21A3526
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on a LD50 value of 464 mg/kg bw for rats (IARC 29 (1982)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an oral rat bone marrow micronucleus test (in vivo somatic cell mutagenicity test) (IARC 71 (1999)), the substance was classified as "Not classified". As relevant information, a negative result is reported in a rat liver UDS test (in vivo genotoxicity tests in somatic cells) (IARC 71 (1999)). From in vitro mutagenicity tests, there are reports of a positive Ames test using Salmonella typhimurium (NTP DB (access on Aug. 2009)), a positive mouse lymphoma test (NTP DB (access on Aug. 2009)) and a positive chromosomal aberration test (NTP DB (access on Aug. 2009)). The substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC 71 (1999)), the substance was classified as "Not classified". As relevant information, in 2-year feeding tests with rats and mice, there were no effects on survival, but there was a significant positive association between concentration administered and the incidences of a combination of urinary bladder neoplasms for female rats and the high dose to control comparison was also significant for these tumors. No compound-related neoplasms were observed in male rats or mice of either sex.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a 7-week feeding test with rats, there was an increased in mortality at 500 mg/kg bw (conversion value) and a decrease in body weight gain at 34 and 340 mg/kg bw (conversion value). There were no other significant effects (IARC 29 (1982)). In a 4-month oral test with rabbits given 20 mg/kg bw, there were no significant effects other than changes in clinical biochemical examination such as increase in alkaline phosphatase (IARC 29 (1982)). In 104-week feeding tests with rats and mice (375 and 750 ppm in rats, 750 and 1500 ppm in mice), there was an increase in inflammation in the kidney at 375 ppm (18.75 mg/kg) and epithelial hyperplasia in the kidney at 750 ppm (37.5mg/kg) in male rats with increased incidence of kidney tumors. There was an increase in inflammation in the kidney at 37.5 mg/kg in female rats (IARC 29 (1982)). These levels are within the guidance value range for Category 2. The substance was classified into Category 2 (kidney) since kidney lesions were observed in male and female rats while it is impossible to rule out association with precancerous lesion.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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