GHS Classification Result

Chemical Name:1-Bromobutane
CAS:109-65-9

Result:
ID: 21A3518
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into Category 2 since flash point is 18 degC (closed-cup) (NFPA (13th, 2006)) and initial boiling point is 101.3 degC (Merck (14th, 2006)). The substance is classified into Class 3, PG II in UNRTDG (UN1126).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 265 degC (Lide (88th, 2008)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on LD50 values of 2761 mg/kg and 3161 mg/kg for rats (HSDB (2006)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on a LC50 value (30 min) of 237 mg/L (4-hour equivalent: 14,952 ppm) for mice (HSDB (2006)), the substance was classified into Category 4. Since the LC50 value was lower than 90% of saturated vapour pressure concentration (309.877 mg/L), it was considered as gas and classification criteria for gas was adopted.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data. Although it is reported as skin irritant in a mouse test (HSDB (2006)), there is no detailed data such as the dose method and degrees of irritation, or additional test results.
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is a report of eye irritant in a rabbit test (HSDB (2006)), there is no detailed data such as the dose method and degrees of irritation, or additional test results. Classification is not possible due to lack of data.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there is a report of no skin sensitization in a mouse LLNA test (HSDB (2006)), classification was not possible since the details are not clear and there are no additional test data.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are results of positives in Ames test and DNA-precipitation assay (HSDB (2006)). In addition, the substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Classification not possible - - - - From Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2007) (104-week inhalation), there is a result that "In F344/DuCrlCrlj (Fischer) rats, no significant increase in the incidence of neoplastic lesions was found by 1-bromobutane-exposure in either sex. It was concluded that there was no evidence of carcinogenic activity in rats. In B6D2F1/Crlj mice, the incidence of bronchiolar-alveolar carcinomas in the lung was increased in males. There was clear evidence of carcinogenic activity in male mice. No significant increases in the incidence of neoplastic lesions was found in females. "Evidence of carcinogenic activity was observed in male mice only and there is a difference in the results of the rat and mouse tests, therefore classification was not possible due to lack of data.
7 Reproductive toxicity Classification not possible - - - - Although there is a report of "in repeated exposure test to pregnant rats, a decreased survival rate among developing embryos and impaired normal development in the postnatal period were found " (HSDB (2006)), there is no detailed experimental data such as the dose method and dosage. No additional test results were included. Classification was not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is a report that labored respiration and ataxia were noted at 1967.9 mg/kg and higher dose levels in a rat oral test (HSDB (2006)), the details are not clear. Classification was not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Vacuolar liver cell degeneration was observed in a test with rats treated by gavage (dose level: 50, 200, 500 mg/kg (90-day equivalent: 15.6, 62.2, 156 mg/kg) for 28 days (HSDB (2006)). Observed effect level is not clear and other findings are not reported. Classification was not possible due to lack of data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 96h-LC50 = 36.7 mg/L for fish (Fathead minnow) (HSDB, 2006).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified into Not classified since it is rapidly degradable (decomposition by BOD degradation rate: 72% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1993)) and its bioaccumulative potential is estimated to be low (log Kow = 2.75 (PHYSPROP Database, 2009)) though its acute toxicity is Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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