Hazard class
|
Classification
|
Symbol
|
Signal word
|
Hazard statement
|
Precautionary statement
|
Rationale for the classification
|
1
|
Acute toxicity (Oral)
|
Not classified
|
-
|
-
|
-
|
-
|
Based on a LD50 value of >36 g/kg bw for rats (IARC 27 (1982)).
|
1
|
Acute toxicity (Dermal)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
1
|
Acute toxicity (Inhalation: Gases)
|
Not applicable
|
-
|
-
|
-
|
-
|
Solid (room temperature)
|
1
|
Acute toxicity (Inhalation: Vapours)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
1
|
Acute toxicity (Inhalation: Dusts and mists)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
2
|
Skin corrosion/irritation
|
Not classified
|
-
|
-
|
-
|
-
|
Based on a result of "not irritating" in rabbit test (IUCLID (2000)).
|
3
|
Serious eye damage/eye irritation
|
Not classified
|
-
|
-
|
-
|
-
|
Based on a report of "not irritating" in a rabbit test (IUCLID (2000)).
|
4
|
Respiratory sensitization
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
4
|
Skin sensitization
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
5
|
Germ cell mutagenicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of negative and positive Ames tests (NTP DB (access on Jul. 2009), IUCLID (2000)), and a positive CHO cell chromosomal aberration test (NTP DB (access on Jul. 2009)). In addition, the substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
|
6
|
Carcinogenicity
|
Not classified
|
-
|
-
|
-
|
-
|
Based on the classification of "Group 3" in IARC (IARC 27 (1982)), the substance was classified as "Not classified". However, the substance was classified into "B" in NTP ROC (NTP ROC No.11 (2005)) based on the conclusion that it is considered to be a carcinogen for rats and mice as there was an increased incidence of hepatocellular carcinomas and malignant lymphomas for mice, and hepatocellular carcinomas and neoplastic nodules of the liver for rats in 78-week feeding test followed by a 15 - 16-week (mice) or 28 - 32-week (rats) post-treatment observation periods (NTP TR144 (1978)). IARC considered above test as "limited evidence for the carcinogenicity in experimental animals due to the low purity the material tested" and concluded "In view of the uncertain purity of the compound tested and in the absence of data on humans, no evaluation of the carcinogenicity could be made". IARC then classified the substance into "Group 3" (IARC 27 (1982)).
|
7
|
Reproductive toxicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
8
|
Specific target organ toxicity - Single exposure
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
9
|
Specific target organ toxicity - Repeated exposure
|
Classification not possible
|
-
|
-
|
-
|
-
|
Although there is a report that in a four week feeding test in rats and mice receiving 1 - 4% in the diet, reductions in weight gain were observed (IARC 27 (1982)), the detailed data are not clear. Additionally, in a 12 - 14 weeks feeding test with rats receiving 1% or 2% in the diet (830 or 1670 mg/kg), females experienced weight loss, emaciation, ataxia, convulsions. All females died within 18 and 21 weeks. Hematological and blood biochemical changes, histopathological findings of kidney damage such as interstitial fibrosis and multitudinous tubular metaplasia as well as bone marrow hyperplasia were observed (IUCLID (2000)).These dose levels exceeded the guidance value range. Therefore classification was not possible due to lack of data for evidence of effects at or near the upper limit of the guidance value range.
|
10
|
Aspiration hazard
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|