GHS Classification Result

Chemical Name:Azodicarbonamide
CAS:123-77-3

Result:
ID: 21A3510
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classified into Not classified since the substance is classified into Division 4.1, PG II in UNRTDG (UN3242) though there are chemical groups (aliphatic azo compound) associated with explosive properties present in the molecules. Oxygen balance is -55.13.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Category 1 Danger H228: Flammable solids P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Classified into Category 1 since commercially pure azodicarbonamide is classified into Division 4.1, PG II in UNRTDG (UN3242) from which the substance is not corresponding to Self-reactive substances and mixtures.
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the commercially pure UN3242 does not correspond to Self-reactive substances and mixtures though there are chemical groups (aliphatic azo compound) associated with explosive properties present in the molecules. Composition of azodicarbonamide may be classified into UN3232(Type B), UN3224, 3234 (Type C), 3226 or 3236 (Type D).
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - The substance does not fall into upper Division 4.2 (Substances liable to spontaneous combustion) since it is classified into Division 4.1, PG II in UNRTDG (UN3242).
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on a LD50 value of 6400 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2000)), no mortality at 5000 mg/kg bw (CICADs 16 (1999)) and no mortality at 6000 mg/kg bw (JECFA (1967) for rats, the substance was classified as "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on a LD50 value of >2000 mg/kg bw for rabbits (CICADs 16 (1999)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - A LC50 value of 61,000 mg/m3/4h (6.1 mg/L/4h) for rats (CICADs 16 (1999)) corresponds to "Not classified". Since the test was conducted for dry aerosol, the classification criteria for "dust and mists" was adopted.
2 Skin corrosion/irritation Not classified - - - - Based on a report that application to the skin of the auricular region of rabbits for 24-hour resulted in "not irritating", the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Based on a result of "not irritating" in a rabbit test (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, in a rabbit test where a mixture of 90% this substance and 10% benzene sulfinic acid, zinc salt was applied, redness and swelling of the conjunctivae were observed but these effects were reversible within 3 days and no corneal changes were observed (IUCLID (2000)).
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
There is a report of a bronchial challenge test providing reasonable evidence that the work-related asthmatic symptoms were due specifically to this substance (CICADs 16 (1999)). According to this report, the delay in response to this substance challenge, the magnitude of reduction in FEV1 accompanied by an increase in airway hyperreactivity were observed in one individual, but a control individual did not respond under similar conditions. Additionally, multiple incidents showing a relationship between occupational exposure to this substance and asthma or respiratory symptoms were reported (IUCLID (2000)). Based on the above data and information, it was concluded that the key toxic effect of this substance in humans is asthmagenicity (CICADs 16 (1999)). Therefore, the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into R42 (EU-Annex I (access on July 2009)).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Since to the poor quality of the only available animal test data, it is not possible to draw any conclusions (CICADs 16 (1999)). However, since on a report of skin sensitization in a male textile worker wearing foam ear plugs, a patch test was conducted to determine the cause of recurrent dermatitis of the ear which resulted in a positive reaction to this substance (CICADs 16 (1999)). Additionally, case reports indicate that patients with dermatitis exposed to this substance at the work place showed a positive reaction with this substance (IUCLID (2000)). Therefore it is concluded that the substance should be considered as a human skin sensitizer (CICADs 16 (1999)), and the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an intraperitoneal injection mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (CICADs No.16 (1999)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there are reports of a positive Ames test (NTP DB (access on Jul. 2009)), a positive CHO cell chromosomal aberration test (NTP DB (access on Jul. 2009)) and a negative mouse lymphoma (L5178Y cell) test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a one-generation reproduction toxicity test by oral administration to rats (OECD TG415 (GLP)), no effects were found in males. Death during the lactation period due to pelvic nephritis-like lesions occurred in the high dose female group (1000 mg/kg). No adverse effects on reproductive parameters of parent animals and viability, growth and morphology of offspring were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2000)). However, since data for developmental toxicity including teratogenicity are insufficient, classification was not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Since no adverse effects were observed by oral administration at 6000 mg/kg to rats or mice (JECFA (1967)), the substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of or insufficient data with other exposure routes.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Reported NOELs in 13-week oral tests are 1000 mg/kg/day for female rats, 2500 mg/kg/day for male mice and 2500 mg/kg/day for female mice (IUCLID (2000)). Additionally, it was reported that no toxicological significant changes were observed at the highest dose of 0.2 mg/L in 13-week inhalation (aerosol) tests with rats and mice (CICADs 16 (1999)). There were no adverse effects by oral administration at 100 - 1000 mg/kg/day for 8 weeks (90-day equivalence: 60 - 600 mg/kg) to rats (JECFA (1967)). The substance corresponds to "Not classified" with oral and inhalation exposure since NOELs or levels without observed adverse effect exceed the upper limit of the guidance value range for Category 2. However, classification was not possible due to lack of dermal exposure data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 48h-EC50 = 11 mg/L for Crustacea (Daphnia magna) (CICAD 16, 1999).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2002)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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