GHS Classification Result

Chemical Name：1-Bromo-3-chloropropane
CAS：109-70-6

Result：
ID: 21A3507
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 57 degC (ICSC (1997)) is >=23 degC and <=60 degC. However, the information is available that the substance is incombustible (Hommel (1996)) and is estimated not to burn continuously. In case of not burning continuously though flash point is above 35 degC, it may not be classified as "Flammable liquids" on "Transport" (Chapter 2.6.2 Note 2 in GHS documents).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Not combustible (Hommel (1996))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (Hommel (1996))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 1300 - 2000 mg/kg (male) and 800 - 1300 mg/kg (female) for rats (OECD TG401 (GLP), "Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on July 2009)),the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of >2000 mg/kg for rats (EEC 84/449/EEC B.3 (GLP), IUCLID(2000)) and 3000 mg/kg for rabbits (IUCLID (2000)), the substance was classified as "Not classified" (correspond to Category 5 in GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LC50 values of 1129 ppm/4h (female) and 1009 ppm/4h (male) for rats (IUCLID (2000)), the substance was classified into Category 3. Since the LC50 values were lower than 90% of saturated vapour pressure concentration (54.3 mg/L (8420 ppmV)), the classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The result of "not irritating" was reported in a test (EEC 84/449/EEC B.3 (GLP)) where after application to the skin of rabbits for 4-hour, edema scores were "1" on days 3 and 4 and "0" at all other points and mean redness scores were "0.67" on day 3, "1" on day 4 and "0" at all other points (IUCLID (2000)). Additionally, in a second rabbit test, after application for 24-hour, primary dermal irritation index was 2.63 (IUCLID (2000)). Based on these results, the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 or "Not classified" in GHS classification).
3 Serious eye damage/eye irritation Not classified - - - - The result of "not irritating" was reported in a rabbit eye irritation test (Directive 84/449/EEC B.5 (GLP)) where temporary corneal opacity and transient iridial inflammation were observed but the effects were completely reversible at 7 days after treatment (IUCLID (2000)). The substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Although the result in a oral mouse dominant lethal test (in vivo heritable germ cell mutagenicity tests) was negative (IUCLID (2000)), there is conflicting information that analysis of bone marrow cells showed a higher number of chromosome aberrations in exposed animals than the control animals in a long term inhalation test (IUCLID (2000)). Therefore, classification was not possible due to difficult-to-determine. As relevant information, from in vitro mutagenicity tests, there are reports of positive for some strains of S. typhimurium and E.coli in bacteria reverse mutation test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on July. 2009)) and a negative in Chinese hamster lung fibroblast cell (CHL) chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on July 2009)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a two-year inhalation test in rats, increased incidences of hepatocellular carcinoma and hepatocellular adenoma in males and hepatocellular carcinoma and hepatocellular adenoma and hemangiosarcoma of the liver in females were observed (Japan Industrial Safety and Health Association: Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare (2004)). In a two-year inhalation test in mice, increased incidences of bronchiolo-alveolar epithelial carcinoma and bronchiolo-alveolar epithelial adenoma in both sexes were observed (Japan Industrial Safety and Health Association: Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare (2004)). Based on these tests there is sufficient evidence to demonstrate animal carcinogenicity to classify the substance into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a rat test by oral administration at 500 - 2000 mg/kg (OECD TG401 (GLP)), clinical signs of decrease in locomotor activity, a prone position and ataxic gait were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on July 2009)). In another rat test by oral administration at 800-1600 mg/kg, clinical signs such as waddling gait, lethargy, decreased respiratory rate were observed (IUCLID (2000)). These dosages are within the guidance value range for Category 2. Additionally, there are report of edema and swelling of neural tissue of the brain as findings in a rat 4-hour inhalation test (vapour: LC50 = 6.5 - 7.27 mg/L) (IUCLID (2000)) and reports of CNS depression in acute experimental animal tests (HSDB (2002)). Although these results of inhalation tests correspond to Category 1 based on guidance value range, the substance was classified into Category 2 because of information in List 2 and a non-GLP test. Based on results of above oral and inhalation tests, the substance was classified into Category 2 (central nervous system). As relevant information, atrophy of the lung and pulmonary edema were observed in above oral rat test (OECD TG401), but this information was not used as the basis of classification since these lesions were observed in dead animals and similar effects were not observed by inhalation exposure.
9 Specific target organ toxicity - Repeated exposure Category 2 (upper respiratory tract, stomach, liver, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (upper respiratory tract, stomach, liver, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In rat and mouse 13-week inhalation tests, morphological changes such as hyperplasia of respiratory epithelia and disarrangement of olfactory epithelia in the nasal cavity and nasopharynx and hyperplasia and erosion of the forestomach were observed. Since the lowest observed effect level of 50 ppm/6h/day (0.322 mg/L/6h/day) is within the guidance value range for Category 2, the substance was classified into Category 2 (upper respiratory tract, stomach). Additionally, in a 28-day repeat dose toxicity test by oral administration to rats (the Chemical Substance Control Law (GLP)), centrilobular hypertrophy of hepatocytes in the animals of both sexes and atrophy of seminiferous tubules in the male animals were observed at 100 mg/kg/day (90-day equivalent: 31.1 mg/kg/day) and higher doses ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on July 2009)). There is a report that liver changes included fatty degeneration and focal proliferation of the interstitial tissue cells, reduction in spermatozoa motility, degenerative changes in spermatogonia and spermatozoa were observed after long term inhalation at 0.045 mg/L to rats (IUCLID (2000)). Since these results indicate adverse effects on the liver and testis at dosing levels within the guidance value range for Category 2 or 1 with oral or inhalation exposure, respectively, and are reported in a document in List 2, the substance was classified into Category 2 (liver, testis).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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