GHS Classification Result

Chemical Name：4-Methylbenzenesulfonic acid
CAS：104-15-4

Result：
ID: 21A3506
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is 600 degC (GESTIS (access on Jul. 2009)) exceeding 70 degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Classification is not possible since no data are available though the substance is a solid (melting point <=55 degC).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		LD50 values are 1410 mg/kg bw (IUCLID (2000), OECD TG 401), 2480 mg/kg bw (IUCLID (2000)) and 400 mg/kg (HSDB (2003)) for rats. Since two values correspond to Category 4 and one value corresponds to "Not classified" in JIS Classification (correspond to Category 5 in GHS classification), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a report of "corrosive" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)), the substance was classified into Category 1. As relevant information, the substance has pH 1 (650 g/L, 20 degC) and is classified into Xi; R36/37/38 in EU classification (EU-Annex I (access on July 2009)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on a result of "corrosive" in a rabbit test (BUA 63 (1991)), the substance was classified into Category 1. As relevant information, the substance is corrosive to skin with a pH 1 (650 g/L, 20 degC).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Based on a report of "not sensitizing" in a guinea pig maximization test (OECD TG406 (GLP)) where no skin reaction was observed (IUCLID (2000), BUA 63 (1991)), the substance was classified as "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test (IUCLID (2000)) and a negative V79 cell chromosome aberration test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity) Warning H371: May cause damage to organs (systemic toxicity) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a oral acute toxicity test with rats (OECD TG401 (GLP)), the following symptoms were observed during the 28-day observation period; impairment of movement, respiration and reflexes, partially closed eyelids, constricted pupils, flow of clear lacrimal fluid, prone or side position, distended abdomen, diarrheas, bad general condition, and impaired body weight development until the end of the experiment in some cases. Necropsy of the animals sacrificed on the 28th day revealed discolouration of the lung, spleen, adrenal glands and of the gastrointestinal tract, and in many cases the stomach, spleen and liver had become partially fused with one another. Almost all deaths occurred during the first day, and necropsy of the dead rats revealed discolouration of liver, pancreas, connective tissue and gastrointestinal tract, hemorrhaging of the gastrointestinal tract and partial detachment of its mucous membrane, and accumulations of a clear, reddish-yellow liquid in the abdominal cavity (BUA 63 (1991)). The LD50 value in this test was 1410 mg/kg (BUA 63 (1991)), within the guidance value range for Category 2 (2000 mg/kg). The affected organ could not be identified due to lack of report in any document. The substance was classified into Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a repeat dose toxicity test with oral dosing to rat for 28 days (OECD TG407 (GLP)), a NOAEL of 100 mg/kg/day (90-day equivalent: 31.1 mg/kg/day) was determined for males. The following observations were reported at 500 mg/kg/day (90-day equivalent: 155.6 mg/kg/day): increased number of animals showing drop in pH of the urine and salivation, organ discolouration (1 or 2 cases in the liver and kidney). No histologically based connection between these findings and the dose administration was evident (BUA 63 (1991)). For females, a NOAEL of 500 mg/kg/day (90-day equivalent: 155.6 mg/kg/day) was determined (BUA 63 (1991)). Therefore, the substance corresponds to "Not classified" for oral exposure since no effects were observed at a dose level exceeding the guidance value range for Category 2 (100 mg/kg/day). However, classification was not possible due to lack of data with other exposure routes.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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