GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Cyclopentanone
CAS：120-92-3
Result：
| ID: | 21A3504 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 3 since flash point 26 degC (closed-cup) (IUCLID (2000)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2245). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Auto-ignition point is 430 degC (Hommel (1996)) exceeding 70 degC. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen which is chemically bonded only to carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on LD50 values of 1200 mg/kg and 2700 mg/kg for rats (JECFA (2003)), the lower value was adopted and the substance was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on a LD50 value of >5000 mg/kg for rabbits (IUCLID (2000)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, although there is information of a LC50 value of 19,500 mg/m3 (5,668 ppmV) (RTECS (2006)), the exposure period is not clear. Since the LC50 value was lower than 90% of saturated vapour pressure concentration (15000 ppm), the test was considered to be conducted for vapour with almost no included mists. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on results of not irritating (skin primary irritation index (PII): 0.31) in a rabbit test (OECD TG404) (IUCLID (2000)) and slightly irritating (PII: 2.75 and 3.0) after application for 4-hour in other two rabbit tests (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 or "Not classified" in GHS classification). As relevant information, in EU classification, the substance is classified into Xi; R36/38 (EU-Annex I (access on July 2009)). |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on results of AOI 54.66 (24-hour) and "highly irritating" in a rabbit test (OECD TG405) (IUCLID (2000)), the substance was classified into Category 2A. As relevant information, in EU classification, the substance is classified into Xi; R36 (EU-Annex I (access on July 2009)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification not possible due to lack of data. There is a report that the substance "produced no sensitization reactions" in a maximization test on 25 volunteers (IUCLID (2000)). This information is reported in a document in List 2 and the positive ratio or data for the control group is not clear. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames Test (JECFA (2003)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In a rat developmental test by oral administration during organogenesis period, no maternal, embryo or fetal toxic effects were observed (JECFA (2003)). In a female mice test involving i.p. injections for 28 days, mating with untreated males on the day 10, there were no effects on fertility (JECFA (2003)). However, this information is incomplete as evidence for classification because of exposure to females only, one dosage and the small number of animals (8/group). Therefore, classification was not possible due to lack of data for sexual function and fertility. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In inhalation tests with rats for 4 - 11 weeks or 11 - 16 weeks, effects on the mitral cells of the olfactory bulb or relationship between concentration of the test substance and drug metabolizing enzymes were reported (IUCLID (2000)). However, these tests are not standard, repeated exposure test, therefore information required for classification are not available because of few examination items. Classification was not possible due to lack of data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Classified into Not classified from its 24h-EC50 = 1435 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Classified into Not classified since it is not non-water soluble (water solubility: 9177 mg/L (PHYSPROP Database, 2009) and its acute toxicity is Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |