GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-Chloro-1,1,1-trifluoroethane
CAS：75-88-7
Result：
| ID: | 21A3502 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Classified into Not classified from the description of "Not combustible gases" (Hommel (1996) Card No. 136). |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Classified into Not classified since the substance is incombustible gas (Hommel (1996) card No. 136). The substance is classified into Division 2.2 in UNRTDG (UN1983). |
| 5 | Gases under pressure | Low pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Critical temperature is 151.86 degC (Lide (88th, 2008)) exceeding 65 degC. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | Based on a LC50 value of 728000 mg/m3/30 min for mice (ECETOC JACC (1990)) (4-hour equivalent: 53,124 ppm), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Three dominant lethal tests in male mice by inhalation (in vivo heritable germ cell mutagenicity tests) were reported. The result of the first test showing positive effect (EHC 139 (1992)) is doubtful due to the low number of mated males and especially low incidence of fetal death in the control group. The second test showing positive effect (EHC 139 (1992)) is difficult to evaluate due to lack of a dose relationship. Finally, the negative result of the third test is employed as a conclusion (ECETOC JACC (1990)). Additionally, a negative result was observed in an inhalation rat bone marrow chromosome aberration test (in vivo somatic cell mutagenicity tests) (EHC 139 (1992)). Based on all data, the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative results for an Ames test and a BHK 21 cell transformation assay. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Based on the classification of "Group 3" in IARC (IARC 71 (1999), the substance was classified as "Not classified". There is a report that the incidences of uterine carcinomas and testicular interstitial-cell neoplasms were significantly increased in a rat test that was terminated at 73-week after 52-week oral administration (IARC 41 (1986)). |
| 7 | Reproductive toxicity | Category 1B |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
In a dominant lethal test in male mice by inhalation, exposure-related decreases in the proportion of pregnant females were observed, histopathological evidence of degeneration of spermatogenic cells was observed and reduced male fertility was observed (EHC 139 (1992)). Additionally, in a rat developmental toxicity test by inhalation during organogenesis period, the ratios of females with total resorptions were increased in a dose-dependent manner and treatment-related increases in the incidence of runts, delayed ossification and hydronephrosis were also observed at doses at which evidence of toxicity in parental animals is not manifested (EHC 139 (1992)). Therefore, the substance was classified into Category 1B. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
A narcotic effect was observed in mice, rats and dogs by inhalation (ECETOC JACC (1990)). Inhalation of high concentrations (738,000 mg/m3 and above) induced convulsions followed by death (EHC 139 (1992)), but recovery from nonlethal exposure is rapid (EHC 139 (1992), therefore the substance was classified into Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Although atrophy of thymus, spleen, testis and ovary, inflammatory changes in the nasal mucosa, emphysema, oedema, bronchitis and pneumonia in the lungs along with changes in hematology, blood clinical chemistry and organ weights were observed in a test where rats were exposed to 48,000 mg/m3 for 90 days; the dose level exceeded the guidance value range. Effects for exposure at approximately the guidance cut-off value were unclear due to lack of data. Therefore, classification was not possible. As relevant information, there is a report that no effects were observed in dogs exposed to 24,000 mg/m3 for 3 months (ECETOC JACC (1990)). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |