GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Sulfur hexafluoride
CAS：2551-62-4
Result：
| ID: | 21A3501 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Not combustible gas (Hommel (1996)) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Classification not possible | - | - | - | - | No data available. |
| 5 | Gases under pressure | High pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | The substance is classified as "High pressure liquefied gas" since critical temperature is 45.6 degC (Merck (14th, 2006), HSDB (2009)) and the substance is liquefied gas under pressure (Hommel (1996)). |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | Based on no effects by 16 - 24-hour exposure at 800,000 ppm (80% with 20% oxygen) to rats (ACGIH (2001)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Although there is a report that 50% of the substance was no more toxic to the eye than water (IUCLID (2000)), the details are not clear. Classification is not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative result in mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (HSDB (2009)), the substance was classified as "Not classified". As relevant information, negative results are reported for the following in vitro tests: Ames test, Chinese hamster ovary cells HGPRT test, and human lymphocytes chromosome aberration test (HSDB (2009)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data. There is information that pharmaceutical agents including the substance, administered at dosages up to 5 mL/kg (40 microL/kg bw as sulfur hexafluoride), did not show any adverse effects on fertility, gestation and litters. No embryo toxicity or teratogenicity was noted and next generation development was normal (EMEA (additional document) 005031 en6). |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance is considered to be essentially a nontoxic gas at 1000 ppm, however since it is heavier than air, asphyxiation by the displacement of air is suggested as the greatest hazard (ACGIH (2001)). It was concluded to be nontoxic in a rat inhalation test where no adverse effect was observed after exposure at 800,000 ppm (PATTY (5th, 2001)). In occupationally exposed workers, signs such as cyanosis, semicomatose, pulmonary oedema and slight acidosis were reported (EHC 227 (2002), PATTY (5th, 2001)), but these signs can be caused by asphyxiation and toxicity of breakdown products (EHC 227 (2002)) or may be caused by impurities (HSDB (2009)). Therefore, the substance was considered to correspond to "Not classified" with inhalation. However, based on reports that the substance has a narcotic effect (PATTY (5th, 2001)) and in very high concentrations has a weak anesthetic effect but is otherwise a virtually inert gas (HSDB (2009)), the substance was classified into Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Although there is a report that the nervous system, liver and kidney were affected in rats and guinea pigs by inhalation (HSDB (2009)), the exposure period or dosage levels are not clear and the report of results is insufficient for classification. Therefore, classification was not possible due to lack of appropriate data that may be used for classification. |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |