GHS Classification Result (Revision of the past classification result)

Chemical Name:Dipotassium nickel(II) tetracyanide
CAS:14220-17-8

Result:
ID: 20A2369
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (room temperature)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (room temperature)
7 Flammable solid Classification not possible - - - - No data available. Regarding inorganic cyanide, it is presumed to be non-combustible.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (room temperature)
10 Pyrophoric solids Classification not possible - - - - No data available. Regarding inorganic cyanide, it is presumed to be non-combustible (and non-pyrophoric).
11 Self-heating substances and mixtures Classification not possible - - - - No data available. Regarding inorganic cyanide, it is presumed to be non-combustible (and not self-heating).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Based on the report that the substance is very soluble in water (Sax 11th, 2004), it was classified into the "Not classified" category.
13 Oxidizing liquids Not applicable - - - - Solid (room temperature)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the mouse LD50 of 275 mg/kg (RTECS (2004); Journal of Pharmaceutical Sciences), the substance was classified into Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (room temperature)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Nickel and its compounds are categorized as respiratory tract sensitizers (Group 2) in Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as respiratory tract sensitizers by the DFG (MAK/BAT No. 43 (2007)). Based on these ratings, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Soluble nickel is classified into skin sensitizers by ACGIH (ACGIH-TLV (2008)). In addition, Nickel and its compounds are categorized into skin sensitizers (Group 1) in Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, Nickel and its compounds are rated as skin sensitizers by the DFG (MAK/BAT No. 43 (2007)). Based on these ratings, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo test results and in vitro mutagenicity test results using several indices. Regarding in vitro mutagenicity tests, chromosomal aberration tests using mouse mammary carcinoma Fm3A cells produced positive results (IARC vol. 49, 1990).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is rated as "Group 1" in IARC 49 (1990), "K" in NTP RoC (11th, 2005) (nickel compounds were classified and "K" is equivalent to Category 1A), "2B" in the Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2004) (nickel was classified and "2B" is equivalent to Category 2), and "A4" in IRIS (1991) and ACGIH-TLV (2004) (soluble inorganic nickel compounds were classified and "A4" is equivalent to the "Not classified" category). Among these widely varying ratings, those by the IARC and NTP were used to classify the substance into Category 1A.
7 Reproductive toxicity Classification not possible - - - - No data available. See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
No test results on this substance are available. However, since soluble inorganic nickel compounds are documented to be respiratory tract irritants according to ACGIH-TLV (2004) and ACGIH (7th, 2001), the substance was classified into Category 3 (respiratory tract irritation). See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
No test results on this substance are available. However, since soluble inorganic nickel compounds are documented to affect the central nervous system (ACGIH TLV-basis critical effects: central nervous system; ACGIH-TLV (2004)), the substance was classified into Category 1 (central nervous system). See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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