GHS Classification Result （Revision of the past classification result）

Chemical Name：Nickel(II) oxide
CAS：1313-99-1

Result：
ID: 20A2366
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Not combustible (ICSC (2004))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It is not combustible (ICSC (2004)) and does not ignite spontaneously in contact with air at room temperature.
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (2004))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is a metal which is insoluble in water (Merck (14th, 2006)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - An inorganic compound containing oxygen (but not fluorine or chlorine). Due to lack of further information, classification is not possible.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the LD50 of > 5000 mg/kg for rats (ECETOC TR 33 (1989)), the substance was classified into the "Not classified" category.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Nickel and its compounds are rated as respiratory tract sensitizers (Group 2) in the Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as respiratory tract sensitizers by the DFG (MAK/BAT No. 43 (2007)). Thus, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It is rated as R43 in the EU classification. In addition, Nickel and its compounds are rated as skin sensitizers (Group 1) in the Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as skin sensitizers by the DFG (MAK/BAT No. 43 (2007)). Thus, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Micronucleus tests using bone marrow or peripheral blood of mice that underwent inhalation exposure (in vivo mutagenicity tests using somatic cell) gave negative results (NTP DB (accessed in January 2009)). Similarly, micronucleus tests using mice or rats that underwent oral or intraperitoneal administration produced negative results (ATSDR (2005)). Based on these negative results, the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity tests, mutation tests using CHO cells gave positive results (ATSDR (2005)), while chromosomal aberration tests using human peripheral blood lymphocytes (EHC 108 (1991)) and Ames tests (NTP DB (accessed in January 2009)) yielded negative results.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "Group 1" by the IARC (IARC 49 (1990)), "A1" by ACGIH (ACGIH (2001)), "Carc. Cat. 1" by the EU (EU-Annex 1 (2009)), and "1" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits (2008)). Based on these ratings, the substance was classified into Category 1A.
7 Reproductive toxicity Classification not possible - - - - In the test in which rats were exposed to the substance through inhalation during the organogenetic period, no effect of exposure on the offspring was detected except for a decrease in body weight at doses that caused reduction of body weight in parental animals. However, this study did not address the effects on sexual functions and fertility of parental animals. Thus, due to insufficient data available, classification is not possible. See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available. See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 13-week inhalation test using rats, granulomatous inflammation and hyperplasia in the bronchial and mediastinal lymph nodes were noted at 0.004 mg Ni/L, which falls under Category 1 guidance doses (ATSDR (2005)). In addition, in a 104 week inhalation test using rats, squamous metaplasia of the amnion, and hyperplasia and fibrosis of the pulmonary alveoli were detected at 0.0006 mg/L, which falls under Category 1 guidance doses (NTP TR-451 (1996)). Also, in a 104-week inhalation test using mice, pulmonary inflammation and hyperplasia in the bronchial lymph nodes were observed at Category 1 guidance doses (NTP TR-451 (1996)). Based on these results, the substance was classified into Category 1 (respiratory system). See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information