GHS Classification Result

Chemical Name:kresoxim-methyl (ISO); methyl (E)-2-methoxyimino-[2-(o-tolyloxymethyl)phenyl]acetate
CAS:143390-89-0

Result:
ID: 20A2331
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available. ((97.2-101.7degC (HSDB (2002)))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 of > 5000 mg/kg bw (JMPR (1998), HSDB (2002)), the substance was classified into the "Not classified" category using the JIS classification criteria (Not classified in the United States classification as well).
1 Acute toxicity (Dermal) Not classified - - - - Based on its rat LD50 of > 2000 mg/kg bw (JMPR (1998)), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 or "Not classified" in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Based on its rat LC50 values of > 5.6 mg/L (JMPR (1998)) and 5.6 mg/L/4h (HSDB (2002)), the substance was classified into the "Not classified" category.
2 Skin corrosion/irritation Not classified - - - - In skin irritation tests using rabbits that underwent 4-hour application, almost no erythema was detected (JMPR (1998)). Similarly, in skin irritation tests using rats, merely mild erythema was observed (JMPR (1998)). Based on these results, the substance was classified into the "Not classified" category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In eye irritation tests using rabbits, conjunctival redness (score: 0.1-4) was noted and it healed after 72 hours (JMPR (1998)). Based on this information, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In maximization tests using guinea pigs (JMPR (1998)), no reaction to the application was noted (JMPR (1998)). Despite this information, classification is not possible due to insufficient data available.
5 Germ cell mutagenicity Not classified - - - - Based on negative results acquired in micronucleus tests using bone marrow of rats or mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (JMPR (1998)), the substance was classified into the "Not classified" category. Also, the following tests gave negative results: DNA damage tests using rat hepatocytes (in vivo genotoxicity tests using somatic cells), Ames tests, gene mutation tests using ovarian cells of Chinese hamsters, and chromosomal aberration tests using human lymphocytes (JMPR (1998)). In chromosomal aberration tests using pneumocytes of Chinese Hamsters, negative results were obtained with metabolic activation system being excluded (-S9) while positive results were obtained with metabolic activation system being included (+S9) (JMPR (1998)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In 24-month oral administration tests using rats, incidences of cancer or adenoma in the liver significantly increased (JMPR (1998)). Due to this information, and because the substance is rated as Category 3 in terms of carcinogenicity in the EU classification, the substance was classified into Category 2.
7 Reproductive toxicity Not classified - - - - In two-generation reproduction studies using rats, no effects of the substance were detected in terms of mating in parental animals, fertility, pregnancy, and live birth index (JMPR (1998)). In addition, in oral route exposure tests conducted during the organogenetic period using rats or rabbits, no effects on the development of offspring were detected (JMPR (1998)). Based on these results, the substance was classified into the "Not classified" category.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using mice or rats, no abnormalities of the organs were found even at a dose (5000 mg/kg bw) above the upper limit of Category 2 guidance values (JMPR (1998)). However, in inhalation tests using rats, non-specific clinical symptoms (accelerated and intermittent respiration, urine-smeared fur, reddish nose, eye discharge, and reddish eyelid crust, etc.) were seen at 2 and 5.6 mg/L concentrations, and these symptoms healed the following day (JMPR (1998)). Based on this information, the substance was classified into Category3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In several oral administration tests using rats (test duration: 28 and 90 days), mice (28 days and 3 months), or dogs (3 and 12 months) (JMPR (1998)), and in dermal administration tests using rats (JMPR (1998)), a decreased body weight, increased liver weight, or other effects on the liver were noted at doses above Category 2 guidance values. However, NOAEL (90-day conversion: 1152 mg/kg/day and 150 mg/kg/day) are higher than Category 2 guidance doses, and no toxicity related to specific target organ toxicity at Category 2 guidance doses was recognized. Though this information leads to classification of the substance into the "Not classified" category (oral and dermal), it was classified into "Classification not possible" because its toxic effects through inhalation route are unknown.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 96-hour EC50 = 0.0551 mg/L for algae (Pseudokirchneriella subcapitata) (AQUIRE, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (BIOWIN), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information