Chemical Name：trifloxystrobin (ISO); (E,E)-alpha-methoxyimino-{2-[[[[1-[3-(trifluoromethyl)phenyl]ethylidene]amino]oxy]methyl]benzeneacetic acid methyl ester
CAS：141517-21-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Its rat LD50 of > 5000 mg/kg bw (JMPR No. 1023 (2004)) falls under the "Not classified" category.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Its rat LD50 of > 2000 mg/kg bw (JMPR No. 1023 (2004)) falls under the "Not classified" category in the JIS classification (Category 5 or "Not classified" in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Its rat LC50 is documented to be > 4.65 mg/L (JMPR No. 1023 (2004)), and this information does not allow to determine classification of the substance between Category 3 and 4.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the conclusion drawn in the rabbit tests that the substance is slightly irritating (JMPR No. 1023 (2004)), it was classified into the "Not classified" category in the JIS classification (Category 3 in the United Nations classification).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Rabbit tests found that the substance is moderately irritating (unwashed) or non-irritating (washed) (JMPR No. 1023 (2004)). Giving priority to "unwashed" conclusion over "washed" one, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Maximization tests using guinea pigs found that the substance is sensitizing while Buehler tests found it non-sensitizing (JMPR No. 1023 (2004)). Since it is rated as R43 in the EU classification, the substance was classified into Category 1.
5	Germ cell mutagenicity	Not classified	-	-	-	-	The classification is based on negative results documented in in vivo mutagenicity tests using somatic cells (chromosomal aberration tests using mouse bone marrow) (JMPR No. 1023 (2004)). Regarding in vitro tests, Ames tests and chromosomal aberration test also gave negative results (JMPR No. 1023 (2004)).
6	Carcinogenicity	Not classified	-	-	-	-	In 18-month mixed diet administration tests using mice, while liver abnormalities were seen in the highest dose groups, no signs of carcinogenicity were detected as occurrence of both malignant lymphoma and neoplasm was not dose-dependent and was consistent with historical control values. In 24-month mixed diet administration tests using rats, no clear cases of dose-dependent abnormalities were noted and no tumorigenesis was detected by autopsy or microscopic examinations (JMPR No. 1023 (2004)). Based on these reports, the substance was classified into the "Not classified" category.
7	Reproductive toxicity	Not classified	-	-	-	-	In two-generation mixed diet administration tests using rats, no effects of administration were found in terms of mortality of parental animals, number of mating, litter size, pregnancy rate, gestation period, number of deliveries, number of surviving offspring, reproductive organs, and reproductive system. The exception was the detection of lower body weight in F2 offspring in high and intermediate dose groups during the lactation period. In the tests in which pregnant rats were orally administered during the organogenetic period, lowered body weight in maternal animals was noted between day 6 and day 16 of pregnancy. No effects on pre- and post-implantation loss, litter size, and fetal body weight were detected. Enlarged thymus in fetuses developed more frequently in 1000 mg/kg groups than in control or historical control records. In the tests in which pregnant rabbits were orally administered during the organogenetic period, suppressed body weight gain was seen for maternal animals in 250 and 500 mg/kg groups, fused third and fourth sternebrae occurred slightly more frequently for fetuses in 500 mg/kg groups than those in control groups while no effects were detected on pre- and post-implantation loss, litter size, and fetal body weight (JMPR No. 1023 (2004)). Based on these reports, the substance was classified into the "Not classified" category.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 3-month mixed diet administration tests using mice, hepatocyte hypertrophy and single hepatocyte necrosis were noted at concentrations above Category 2 guidance values. In 28-day and 90-day mixed diet administration tests using rats, an increased liver weight was detected; however, no microscopic observations were conducted and concentrations tested were above Category 2 guidance values. In 52-week oral administration (capsules) tests using dogs, an increased liver weight, and increased incidences and severity of hepatocyte hypertrophy were detected at the concentrations that fall under Category 2 guidance values (JMPR No. 1023 (2004)). Based on these reports, the substance was classified into Category 2 (liver).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 96-hour LC50 = 0.00862 mg/L for crustaceans (Mysidopsis bahia) (AQUIRE, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its classification for acute toxicity is Category 1, and information on its rapid degradability has not been acquired, the substance was classified into Category 1.