GHS Classification Result

Chemical Name:chlorfenapyr; 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethylpyrrole-3-carbonitrile
CAS:122453-73-0

Result:
ID: 20A2320
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing fluorine, chlorine, and oxygen, which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Its rat LD50 was documented to be 626 mg/kg in one study (EPA. PESTICIDE (2001)); in another study, it was found to be 461 mg/kg for males and 304 mg/kg for females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). All these values fall under the range of Category 4 guidance values.
1 Acute toxicity (Dermal) Not classified - - - - Since its rabbit LD50 value is > 2000 mg/kg (EPA. PESTICIDE (2001), and A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center (2008)), the substance was classified into "Not classified" (Category 5 or "Not classified" category in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the results that its mouse LC50 values are 0.83 mg/L for males and > 2.7 mg/L for females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) and its EU Risk Phrase of R23, the substance was classified into Category 3.
2 Skin corrosion/irritation Not classified - - - - In GLP-compliant primary skin irritation tests using rabbits, the substance was documented to be not skin irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)); thus, it was classified into "Not classified". The EPA. PESTICIDE (2001) also reported similar test results.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In primary skin irritation tests using rabbits, corneal clouding, iritis, and conjunctivitis were noted after 48 hours, and all affected animals fully recovered within 7 days (EPA. PESTICIDE (2001). In addition, there the information that the substance is mildly irritating to ocular-mucous membrane (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Based on these study results, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Negative results obtained in Buehler tests using guinea pigs (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) and maximization tests using guinea pigs (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) indicate the classification of the substance into the "Not classified" category. However, since these results were acquired using List 2 datasets, the substance was classified into "Classification not possible".
5 Germ cell mutagenicity Not classified - - - - Based on negative results found in in vivo mutagenicity tests using somatic cells (micronucleus tests using bone marrow cells of mice that underwent oral administration) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)), the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity studies, Ames tests, HGPRT mutation tests using CHO cells (GLP-compliant), and chromosomal aberration tests using CHL cells all yielded negative results (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)) while chromosomal aberration tests using CHO cells found positive results only at high administration doses (EPA. PESTUCIDE (2001)).
6 Carcinogenicity Classification not possible - - - - In chronic toxicity / carcinogenicity joint tests using rats, administration of the substance up to approximately 30 mg/kg/d for 2 years did not affect incidences of tumorigenesis, and it was found to be non-carcinogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Similarly, in carcinogenic tests using mice, administration of the substance up to approximately 35 mg/kg/d for 18 months did not affect frequencies of developing neoplastic lesions, and it was found to be non-carcinogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). These results indicate that the substance is to be classified into the "Not classified" category; however, since they were obtained using List 2 datasets, the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - In 2-generation reproduction tests using rats (GLP-compliant), concentrations of mixed diet administration from 60 to 600 ppm did not affect neither fertility nor any indices related to morphological differentiation after birth (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). In addition, in oral administration tests conducted during the organogenetic period using rats (dose: 25-225 mg/kg/d), administration had no effects on any inspection items related to reproductive toxicity, and it was found to be non-teratogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Also, in oral administration tests conducted during the organogenetic period using rabbits (dose: 5-30 mg/kg/d), administration had no effects on any inspection items related to implantation and fetuses, and it was found to be non-teratogenic (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). These results indicate that the substance is to be classified into the "Not classified" category; however, since they were obtained using List 2 datasets, the substance was classified into "Classification not possible". The above-mentioned studies are reported by ESA. PESTICIDE (2001) as well.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In orally administered rapid neurotoxicity tests using rats (GLP-compliant), lethargy was seen in 5 out of 20 rats treated with 180 mg/kg, and 2 out of 20 rats in 90 mg/kg groups; and functional examinations found abnormal gait, dyskinesia, and lowered levels of alertness in 180 mg/kg groups (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). These results indicate that the substance is to be classified into Category 1 (nervous system); however, since they were obtained using List 2 datasets, the substance was classified into Category 2 (nervous system). As additional information, in acute oral toxicity tests using rats (GLP-compliant), though doses administered cannot be confirmed, dyspnea or clonic convulsions were observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Also, in general pathological studies using rats (Irwin method), raised body temperatures, clonic convulsions, and abnormal gait, etc. were observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 90-day repeated oral administration tests using rats, administration of approximately 90 to 100 mg/kg/d showed increased GPT and gamma-GTP in males, and increased gamma-GTP in females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). In 4-week repeated dermal exposure tests using rabbits, administration of 400-1000 mg/kg/d (90-day conversion: 107-270 mg/kg/d) showed no effects other than vacuolization of hepatocyte cytoplasm and an increased GPT (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). On the other hand, motor ataxia in male rats and decreased activities were reported in the above-mentioned rat tests; moderate to extensive, reversible vacuolization was detected in the cerebral cortex and optic nerves in 90-day repeated oral administration tests using mice (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)); and similar reversible neuropathy was observed in mice that received administration for 52 weeks (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2008)). Since doses used in these tests fall under the range of Category 2 guidance values, the substance was classified into Category 2 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 24-96-hour LC50 = 0.0061 mg/L for crustaceans (Daphnia) (HSDB, 2007), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (BIOWIN), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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