Chemical Name：1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol
CAS：107534-96-3

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Of its rat LD50 values documented: 1700, 3350, 3930, 4000, 4260, and > 5000 mg/kg bw (JMPR No. 884 (1994)), "Not classified" category was represented by the largest number of values (from 3350 to > 5000 mg/kg). Thus, the substance was classified into "Not classified" using the JIS classification criteria. Also, all LD50 values documented above except for > 5000 mg/kg fall under Category 5 in the United Nations classification.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Its rat LD50 values are > 5000 and > 2000 mg/kg bw (JMPR No. 884 (1994)) and both values fall under "Not classified" category. Thus, the substance was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Of its rat LD50 values documented: 0.818, 0.371, and 5.093 mg/L (JMPR No. 884 (1994)), each of them represents Category 2, Category 3, or "Not classified". Selecting the value representing the highest toxicity, the substance was classified into Category 2. Regarding its LD50 value of 0.818 mg/L, since the test concentration of > 818 mg/m3 (= > 0.818 mg/L) was higher than its saturated vapour pressure concentration of 27.70*e-11 (mg/L) at 25degC, we judged that the experiment was conducted in dust/mist state.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since all three separate dermal irritation tests using rabbits that underwent 4-hour application gave negative results (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2006)), the substance was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In rabbit tests, application of 50 mg caused no irritation (JMPR No. 884 (1994)), and application of 100 mg caused slight irritation (JMPR No. 884 (1994)). Based on these results, the substance was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Not classified	-	-	-	-	Maximization tests using guinea pigs could not determine whether the substance is sensitizing, while the tests using the Buehler method gave negative results. However, since other tests using the maximization method or Buehler method (both are GLP tests) both gave negative results (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2006)), the substance was classified into "Not classified".
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative results acquired in both dominant lethal tests using mice that underwent oral administration and micronucleus tests (both are in vivo mutagenicity tests using somatic cells) (JNPR No. 884 (1994)), the substance was classified into "Not classified". Regarding in vitro mutagenicity tests, both Ames tests and mutation tests using CHO cells gave negative results (JMPR No. 884 (1994)).
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 2-year oral administration tests using rats, no increase in tumorigenesis was detected, whereas in 21-month oral administration tests using female mice, a significant increase in rates of developing hepatic adenoma and carcinoma were discovered (JMPR No. 884 (1994)); thus, the substance was classified into Category 2.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In oral administration tests using rats conducted during the organogenetic period, an increased post-implantation loss, increased incidences of peromelia, agenesis of claws, and cleft palates were detected at the doses associated with suppressed body weight gain in maternal animals (JMPR No. 884 (1994)). In addition, in other oral administration tests using rats conducted during the organogenetic period, a decreased reproduction rate, increased in number of underdeveloped animals, and increased microphthalmia were detected at the doses associated with suppressed body weight gain in maternal animals (JMPR No. 884 (1994)). Based on these results, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In oral administration tests using rats, a state of sedation was observed in female rats at 950 mg/kg and male rats at 1600 mg/kg, and the symptom disappeared in 2 days. Similarly, in other tests, a state of sedation was observed and disappeared in 3 days. In addition, in other tests, lowered activities, prone posture, recumbency, and slowed reflexes were detected at Category 2 guidance doses; and in mice a lowered rate of activity, slowed reflexes, prone posture, and recumbency were also detected at Category 2 guidance doses (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2006)). Based on these results, the substance was classified into Category 2 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 2 (eye)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (eye)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	One-year oral administration tests using beagle dogs (12 females and 12 males) found that NOAEL for cataract induction is 4.5 mg/kg (JMPR No. 884 (1994)). In other tests using beagle dogs that were treated with doses above this NOAEL value, lens opacities were observed in 2 dogs treated with 10 mg/kg/day and one dog treated with 60 mg/kg/day during the weeks 26 and 32 of the test period (JMPR No. 884 (1994)). Based on these results, the substance was classified into Category 2 (eyes). In other reports, oral administration tests using rats found fatty changes in the liver, bile-duct proliferation, and enlargement of the centrilobular hepatocytes (JMPR No. 884 (1994)); however, we considered these could be adaptive changes and did not use these results as grounds for classification. Also, sclerosis of the red pulp of the spleen, associated with sideropenia was mentioned in the same study; however, since no details were provided, we did not use this report either.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 96-hour LC50 is 0.49 mg/L for crustaceans (mysids) (AQUIRE, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.