Chemical Name：N-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)-phenyl-aminocarbonyl]-2,6-difluorobenzamide
CAS：103055-07-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on its rat LD50 of > 5000 mg/kg (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))), the substance was classified into "Not classified".
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available. It is rated as R43 in the EU classification (EU-Annex 1 (accessed in February 2009)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Though the administration route is not provided, micronucleus tests using mice (in vivo mutagenicity tests using somatic cells) yielded negative results (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))). Given these results, the substance was classified into "Not classified". Negative results were also found in the following tests: unscheduled DNA synthesis tests using rat hepatocytes (in vivo genotoxicity tests using somatic cells), in vitro tests including unscheduled DNA synthesis tests using rat hepatocytes or human fibroblasts, and chromosomal aberration tests using CHO cells (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))).
6	Carcinogenicity	Classification not possible	-	-	-	-	In carcinogenicity tests using rats or mice that underwent mixed diet administration, no signs of carcinogenicity were detected (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))). These results indicate that the substance is to fall under the "Not classified" category. However, since these results were acquired using List 2 datasets, the substance was classified into "Classification not possible".
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In teratogenicity tests using rats that underwent forced oral administration with unspecified administration duration, while no signs of teratogenicity were detected in offspring, decreased average number of implantations and decreased average number of surviving fetuses were detected in parental animals (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))). Based on this report, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, nervous system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver, nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In repeated oral administration tests using mice (18-month tests), rats (24-month tests), or dogs (12-month tests), effects of the administration on the liver including adipose degeneration, necrotic changes, hepatocyte hypertrophy, and increased relative weight of the liver, as well as tonic and clonic convulsions and tremors were commonly detected across animal species tested at Category 2 guidance doses (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))). In 4-month neurotoxicity tests using rats that underwent oral administration, no abnormalities were detected in groups administered at 27.15 mg/kg/day, which falls under Category 2 guidance doses, in neuropathological examinations; however, pentylenetetrazol-induced convulsions were strengthened and then lessened during recovery tests (Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))). According to Pesticide safety information (Japan Crop Protection Association) (FOOD SANITATION RESEARCH vol.51 No.10 (2001))), the following observations have been made: this substance has a high lipid solubility and its degradability in the body is so low that it is presumably accumulated easily in the body, and because this substance promotes pentylenetetrazol-induced convulsions, it presumably acts on the brain stem and cerebral cortex. Consequently, this substance may accumulate in lipid of the cells around the nervous system which is the fatty part of the brain, and when its concentration becomes above a certain level, the substance is considered to impact neurotransmission system. Based on these documents, the substance was classified into Category 2 with its target organs set as the liver and nervous system.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.