GHS Classification Result

Chemical Name:2,3,5,6-tetrahydro-2-methyl-2H-cyclopenta[d]-1,2-thiazol-3-one
CAS:82633-79-2

Result:
ID: 20A2304
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available. There is a description that the substance is not flammable (NICNAS (1996)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available. There is a description that the substance is not flammable (NICNAS (1996)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
In rat tests (directive 92/69/EEC (1) Test B.1 NICNAS (1996)), LD50 values were estimated as 224 mg/kg for male rats and 168 mg/kg for female rats (NICNAS (1996)). Based on these values, the substance was classified into Category 3. It is rated as T; R25 in the EU classification.
1 Acute toxicity (Dermal) Classification not possible - - - - In the tests using male rats, no mortality occurred at doses up to 1000 mg/kg (NICNAS (1996)). This result indicates that the substance falls under Category 4 or "Not classified" category; however, due to lack of additional data, it was classified into the "Classification not possible" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In rabbit tests (directive 92/69/EEC (1) Test B.4 NICNAS (1996)), mild erythema and edema were detected, and average scores for erythema and edema were less than 1.5 in evaluations conducted in 24, 48 and 72 hours (NICNAS (1996)). Average scores of less than 1.5 for erythema and edema represent the "Not classified" category. It is documented that 9-day repeated toxicity (dermal route) tests using rats showed severe irritation and necrosis (NICNAS (1996)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
In the tests in which the substance was applied to the eyes of rabbits (directive 92/69/EEC (1) Test B.5 NICNAS (1996)), severe erythema (Draize score: 3), chemosis (Draize score: 4), mild eye mucus (Draize score: 1), and moderate erythema in eyelids were observed 1 hour after application, leading to the conclusion that the substance is an extremely severe irritant. Based on this report, the substance was classified into Category 1. It is rated as Xi; R41 in the EU classification.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
The tests using guinea pigs (directive 92/69/EEC (1) Test B.6 NICNAS (1996)) found that the substance is a strong irritant (18 out of 20 rats after 24 hours at 0.3%; 9 out of 20 rats after 48 hours at 0.3%; 20 out of 20 rats after 24 hours at 1%; and 20 out of 20 rats after 48 hours at 1%), and it is rated as R43 by the EU. Thus, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on negative results obtained in micronucleus tests using mouse bone marrow cells (in vivo mutagenicity tests using somatic cells) (directive 92/69/EEC (1) Test B.12 NICNAS (1996)), the substance was classified into "Not classified". Negative results were also reported in vivo genotoxicity tests using somatic cells (unscheduled DNA synthesis tests using mouse liver) (NICNAS (1996)). In addition, regarding in vitro mutagenicity tests, gene mutation tests using microorganisms (directive 92/69/EEC (1) Test B.14), gene mutation tests using cultured mammalian cells, and non-bacteriological in vitro tests (directive 92/69/EEC (1) Test B.10) all gave negative results (NICNAS (1996)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In single oral administration tests using rats (directive 92/69/EEC (1) Test B.1), no effects of administration were detected in male rats and slight toxicity was detected in female rats at a 50 mg/kg concentration, and toxic symptoms were observed for 4 days. At a 100 mg/kg concentration, extreme toxic symptoms were detected in one female rat, and at 500 mg/kg, all treated animals showed extreme toxic symptoms (NICNAS (1996)). In spite of these results documented, the substance was classified into "Classification not possible" due to insufficient data on general symptoms, hematological and biochemical changes, and pathological observations.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - According to 28-day oral administration tests using rats fed on mixed diet (directive 92/69/EEC (1) Test B.7 NICNAS (1996)), no effects of administration were detected other than an increased testis weight in male rats at 1000 ppm which was the highest dose tested (90-day conversion: 16.7 mg/kg, which falls under Category 2 guidance value range). However, due to insufficient data available, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 72-hour EC50 = 0.55 mg/L for algae (Pseudokirchneriella subcapitata) (NICNAS, 1996), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Its classification for acute toxicity is Category 1, and we judged that it is not rapidly degradable as reliable information on its rapid degradability was not available. Thus, the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information